/pdf/testamento-do-vilao-invencao-e-recepcao-da-poesia-de-3vqykw9k4m.pdf

Testamento do vilão: invenção e recepção da poesia de François Villon

The Middle Ages, the Other

The rapid emergence of multiple strains of Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) has sparked profound concerns regarding the ongoing evolution of the virus and its potential impact on global health. Classified by the World Health Organization (WHO) as variants of concern (VOC), these strains exhibit heightened transmissibility and pathogenicity, posing significant challenges to existing vaccine strategies. Despite widespread vaccination efforts, the continual evolution of SARS-CoV-2 variants presents a formidable obstacle to achieving herd immunity. Of particular concern is the coronavirus spike (S) protein, a pivotal viral surface protein crucial for host cell entry and infectivity. Mutations within the S protein have been shown to enhance transmissibility and confer resistance to antibody-mediated neutralization, undermining the efficacy of traditional vaccine platforms. Moreover, the S protein undergoes rapid molecular evolution under selective immune pressure, leading to the emergence of diverse variants with distinct mutation profiles. This review underscores the urgent need for vigilance and adaptation in vaccine development efforts to combat the evolving landscape of SARS-CoV-2 mutations and ensure the long-term effectiveness of global immunization campaigns. 

Mutational Dynamics of SARS-CoV-2: Impact on Future COVID-19 Vaccine Strategies

Studying the medieval prosimetrum, a genre that mixes narrative with lyric, could have important ramifications for the general study of poetics. By disrupting transhistorical theories of the lyric, which proceed from a presumed continuity between ancient Greece and modernity, the prosimetrum situates the Middle Ages at the center of our understanding of modern lyric poetry. Instead of beginning with a late-eighteenth-century understanding of lyric poetry as a self-expressive voice, which scholars must then localize in a poem's historical conditions, language, and genres, the prosimetrum begins with a conventional, rhetorical poem in a variety of stated genres and then, by including a narrative frame, stages that poem as a heartfelt song sung by lovesick knights or clerks. In the prosimetrum, the playful game of conventional art, which defines the medieval love lyric in isolation, suddenly becomes a way to imagine fictional subjectivities.

Song in Reverse: The Medieval Prosimetrum and Lyric Theory

SARS-CoV-2 continues to pose a global threat, and current vaccines, while effective against severe illness, fall short in preventing transmission. To address this challenge, there’s a need for vaccines that induce mucosal immunity and can rapidly control the virus. In this study, we demonstrate that a single immunization with a novel gorilla adenovirus-based vaccine (GRAd) carrying the pre-fusion stabilized Spike protein (S-2P) in non-human primates provided protective immunity for over one year against the BA.5 variant of SARS-CoV-2. A prime-boost regimen using GRAd followed by adjuvanted S-2P (GRAd+S-2P) accelerated viral clearance in both the lower and upper airways. GRAd delivered via aerosol (GRAd(AE)+S-2P) modestly improved protection compared to its matched intramuscular regimen, but showed dramatically superior boosting by mRNA and, importantly, total virus clearance in the upper airway by day 4 post infection. GrAd vaccination regimens elicited robust and durable systemic and mucosal antibody responses to multiple SARS-CoV-2 variants, but only GRAd(AE)+S-2P generated long-lasting T cell responses in the lung. This research underscores the flexibility of the GRAd vaccine platform to provide durable immunity against SARS-CoV-2 in both the lower and upper airways.

Durable immunity to SARS-CoV-2 in both lower and upper airways achieved with a gorilla adenovirus (GRAd) S-2P vaccine in non-human primates

La Vie de la lettre au Moyen Age (Le Conte du Graal)

Lecture du Lais et du Testament: le systeme contredit de l'ecriture de V., recherche de l'autre du sens, d'une langue virginale, et processus de depouillement et de retrait. Parole a double fil, equivocite et parite du dire ou se jouent une parturition et un deuil. Les noms de "F." et de "V"., pris dans un reseau de motivations, assument dans l'oeuvre la fonction de metaphore conductrice d'une langue brisee en deux voix discordantes, dans la fissure de laquelle s'ecrit le poete.

Le Contredit de Francois Villon

Background. SARS-CoV-2 ongoing pandemic and heterologous immunization approaches implemented worldwide for booster doses call for diversified vaccines portfolio. We report safety and immunogenicity of GRAd-COV2, a novel gorilla adenovirus-based COVID-19 vaccine, in a phase 2 trial aimed at identifying the appropriate dose and schedule. Method. 917 eligible adults aged 18 years or older, including participants with co-morbidities, were randomised to receive, 21 days apart, a single vaccine administration at 2x1011 viral particles (vp) followed by placebo, or repeated vaccine administration at 1x1011 vp, or two doses of placebo. Primary endpoints were the incidence of local and systemic solicited AEs for 7 days post each dose and the post-treatment (35 days after the first dose), geometric mean titers (GMTs) and geometric mean fold rise (GMFRs) of ELISA antibody responses to Spike protein. Additional humoral and cellular immune response parameters were monitored for up to six months. Results. The safety profile of GRAd-COV2 was characterized by short-term, mild-to-moderate pain and tenderness at injection site, fatigue, headache, malaise, and myalgia. Neither related SAEs nor deaths were reported. Humoral (binding and neutralizing) Ab responses peaked at day 35 after a single administration, were boosted by a second vaccination, were sustained until day 57 to then decline at day 180. Potent, VOC cross-reactive T cell responses peaked already after first dose with high frequencies of long-lived CD8 T cells. Conclusion. GRAd-COV2 was safe, and induced robust immune responses after a single immunization; the second administration increased humoral but not cellular immune responses.

/pdf/grad-cov2-vaccine-provides-potent-and-durable-immunity-in-a-125ztriv.pdf

GRAd-COV2 vaccine provides potent and durable immunity in a randomised placebo-controlled phase 2 trial (COVITAR)

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La Vie de la lettre au Moyen Age (Le Conte du Graal)

Le Contredit de Francois Villon

GRAd-COV2 vaccine provides potent and durable immunity in a randomised placebo-controlled phase 2 trial (COVITAR)