Roger Cachope
CHDI Foundation
39 Papers
134 Citations
Roger Cachope is an academic researcher from CHDI Foundation. The author has contributed to research in topics: Nucleus accumbens & Dopamine. The author has an hindex of 16, co-authored 29 publications. Previous affiliations of Roger Cachope include Yeshiva University & Albert Einstein College of Medicine.
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Papers
Selective activation of cholinergic interneurons enhances accumbal phasic dopamine release: setting the tone for reward processing
Roger Cachope,Yolanda Mateo,Brian N. Mathur,James M. Irving,Hui-Ling Wang,Marisela Morales,David M. Lovinger,Joseph F. Cheer +7 more
TL;DR: It is demonstrated that in vivo selective activation of cholinergic interneurons is sufficient to elicit dopamine release in the nucleus accumbens and results from a complex convergence of neurotransmitter/neuromodulator systems that may ultimately synergize to drive motivated behavior.
511
Ventral hippocampal afferents to the nucleus accumbens regulate susceptibility to depression
Rosemary C. Bagot,Eric M. Parise,Catherine Jensen Pena,Hongxing Zhang,Ian Maze,Dipesh Chaudhury,Brianna Persaud,Roger Cachope,Carlos A. Bolaños-Guzmán,Joseph F. Cheer,Karl Deisseroth,Ming-Hu Han,Eric J. Nestler +12 more
TL;DR: It is demonstrated that glutamatergic vHIP afferents to NAc regulate susceptibility to chronic social defeat stress (CSDS), highlighting an important, novel circuit-specific mechanism in depression.
ΔFosB Induction in Striatal Medium Spiny Neuron Subtypes in Response to Chronic Pharmacological, Emotional, and Optogenetic Stimuli
Mary Kay Lobo,Samir Zaman,Diane M. Damez-Werno,Ja Wook Koo,Rosemary C. Bagot,Jennifer A. DiNieri,Alexandria L. Nugent,Eric Finkel,Dipesh Chaudhury,Ramesh Chandra,Efrain Riberio,Jacqui Rabkin,Ezekiell Mouzon,Roger Cachope,Joseph F. Cheer,Ming-Hu Han,David M. Dietz,David W. Self,Yasmin L. Hurd,Vincent Vialou,Eric J. Nestler +20 more
TL;DR: It is demonstrated that chronic exposure to many stimuli induces ΔFosB in an MSN-subtype selective pattern across all three striatal regions, and novel insight is provided into the circuit-level mechanisms of ΔFOSB induction in striatum.
239
Unravelling and Exploiting Astrocyte Dysfunction in Huntington's Disease.
Baljit S. Khakh,Vahri Beaumont,Roger Cachope,Ignacio Munoz-Sanjuan,Steven A. Goldman,Steven A. Goldman,Rosemarie Grantyn +6 more
TL;DR: The data suggest that astrocyte dysfunction is an important contributor to the onset and progression of some HD symptoms in mice and may provide new therapeutic opportunities to explore in conjunction with neuronal rescue and repair strategies.
233
Local control of striatal dopamine release.
TL;DR: These developments involving genetic manipulation, pharmacological selectivity or selective stimulation transform considerably the authors' understanding of the mesolimbic and nigrostriatal systems, and have strong implications as potential mechanisms to modify impaired control of DA release in the diseased brain.