Roel Sterken
Columbia University
10 Papers
46 Citations
Roel Sterken is an academic researcher from Columbia University. The author has contributed to research in topics: Gene & Quantitative trait locus. The author has an hindex of 9, co-authored 10 publications. Previous affiliations of Roel Sterken include Flanders Institute for Biotechnology & Ghent University.
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Papers
Copy-Number Disorders Are a Common Cause of Congenital Kidney Malformations
Simone Sanna-Cherchi,Krzysztof Kiryluk,Katelyn Elizabeth Burgess,Monica Bodria,Matthew G. Sampson,Dexter Hadley,Shannon N. Nees,Miguel Verbitsky,Brittany J. Perry,Roel Sterken,Vladimir J Lozanovski,Anna Materna-Kiryluk,Cristina Barlassina,Akshata Kini,Valentina Corbani,Alba Carrea,Danio Somenzi,Corrado Murtas,Nadica Ristoska-Bojkovska,Claudia Izzi,Beatrice Bianco,Marcin Zaniew,Hana Flögelová,Patricia L. Weng,Nilgun Kacak,Stefania Giberti,Maddalena Gigante,Adela Arapović,Kristina Drnasin,Gianluca Caridi,Simona Curioni,Franca Allegri,Anita Ammenti,Stefania Ferretti,Vinicio Goj,Luca Bernardo,Vaidehi Jobanputra,Wendy K. Chung,Richard P. Lifton,Stephen Sanders,Matthew W. State,Lorraine N. Clark,Marijan Saraga,Sandosh Padmanabhan,Anna F. Dominiczak,Tatiana Foroud,Loreto Gesualdo,Zoran Gucev,Landino Allegri,Anna Latos-Bielenska,Daniele Cusi,Francesco Scolari,Velibor Tasic,Hakon Hakonarson,Gian Marco Ghiggeri,Ali G. Gharavi +55 more
TL;DR: The majority of the known CNV disorders detected in the RHD cohort have previous associations with developmental delay or neuropsychiatric diseases and should be considered in this population for the diagnosis of their specific genomic disorders and for the evaluation of the potential for developmental delay.
Combined linkage and association mapping reveals CYCD5;1 as a quantitative trait gene for endoreduplication in Arabidopsis
Roel Sterken,Raphaël Kiekens,Joanna Boruc,Fanghong Zhang,Annelies Vercauteren,Ilse Vercauteren,Lien De Smet,Stijn Dhondt,Dirk Inzé,Lieven De Veylder,Eugenia Russinova,Marnik Vuylsteke +11 more
TL;DR: It is shown that variation in endoreduplication between Arabidopsis thaliana accessions Columbia-0 and Kashmir is controlled by two major quantitative trait loci, ENDO-1 andENDO-2.
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Genome-wide screening for cis-regulatory variation using a classical diallel crossing scheme
Raphaël Kiekens,Annelies Vercauteren,Beatrijs Moerkerke,Els Goetghebeur,Hilde Van den Daele,Roel Sterken,Martin Kuiper,Fred A. van Eeuwijk,Marnik Vuylsteke +8 more
TL;DR: A quantitative genetics approach to perform a genome-wide analysis of ASE differences (GASED), based on a diallel design, that can accelerate systematic surveys of naturally occurring cis-regulatory variation among inbred lines for laboratory species, such as Arabidopsis, mouse, rat and fruitfly, and economically important crop species.
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A Population Genomics Study of the Arabidopsis Core Cell Cycle Genes Shows the Signature of Natural Selection
Roel Sterken,Roel Sterken,Raphaël Kiekens,Raphaël Kiekens,Emmy Coppens,Emmy Coppens,Ilse Vercauteren,Ilse Vercauteren,Marc Zabeau,Marc Zabeau,Dirk Inzé,Dirk Inzé,Jonathan M. Flowers,Marnik Vuylsteke,Marnik Vuylsteke +14 more
TL;DR: It is found that the Arabidopsis core cell cycle (CCC) machinery is not highly constrained but is subject to different modes of selection, and the genetic robustness of cell cycle–related processes is more due to functional redundancy than high selective constraint.
24
A retrotransposon insertion in the 5' regulatory domain of Ptf1a results in ectopic gene expression and multiple congenital defects in Danforth's short tail mouse.
Francesca Lugani,Ripla Arora,Natalia Papeta,Ami Patel,Zongyu Zheng,Roel Sterken,Ruth A. Singer,Gianluca Caridi,Cathy Mendelsohn,Lori Sussel,Virginia E. Papaioannou,Ali G. Gharavi +11 more
TL;DR: Disruption of the spatio-temporal pattern of Ptf1a expression is identified as the unifying mechanism underlying the multiple congenital defects in Danforth's short tail mouse, suggesting that disruption of conserved regulatory elements may also contribute to human malformation syndromes.