Roderick McNab
University of Otago
24 Papers
792 Citations
Roderick McNab is an academic researcher from University of Otago. The author has contributed to research in topics: Streptococcus gordonii & Actinomyces naeslundii. The author has an hindex of 16, co-authored 24 publications. Previous affiliations of Roderick McNab include University College London & University Of Bristol Dental Hospital.
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Papers
LuxS-Based Signaling in Streptococcus gordonii: Autoinducer 2 Controls Carbohydrate Metabolism and Biofilm Formation with Porphyromonas gingivalis
Roderick McNab,Suzannah K. Ford,Azza El-Sabaeny,Bruno Barbieri,Guy S. Cook,Richard J. Lamont +5 more
TL;DR: The results suggest that Streptococcus gordonii produces an AI-2-like signaling molecule that regulates aspects of carbohydrate metabolism in the organism, and LuxS-dependent intercellular communication is essential for biofilm formation between nongrowing cells of P. gingivalis and S. g Gordonii.
384
The pavA gene of Streptococcus pneumoniae encodes a fibronectin‐binding protein that is essential for virulence
Ann R. Holmes,Roderick McNab,Kevin W. Millsap,Manfred Rohde,Sven Hammerschmidt,Jane L. Mawdsley,Howard F. Jenkinson +6 more
TL;DR: Evidence is provided that PavA fibronectin‐binding protein plays a direct role in the pathogenesis of pneumococcal infections.
255
Candida albicans binding to the oral bacterium Streptococcus gordonii involves multiple adhesin-receptor interactions.
TL;DR: Holmes et al. as mentioned in this paper showed that isogenic cell surface protein mutants of S. gordonii DL1, unaltered in expression of cell wall polysaccharide, are reduced in ability to support adherence of C. albicans cells in a solid-phase assay.
146
Tandem genes encode cell-surface polypeptides SspA and SspB which mediate adhesion of the oral bacterium Streptococcus gordonii to human and bacterial receptors
TL;DR: The results suggest that both SspA and SspB polypeptides are involved in adhesion of S. gordonii cells to human and bacterial receptors.
138
Cell Wall-Anchored CshA Polypeptide (259 Kilodaltons) in Streptococcus gordonii Forms Surface Fibrils That Confer Hydrophobic and Adhesive Properties
Roderick McNab,Helen Forbes,Pauline S. Handley,Diane M. Loach,Gerald W. Tannock,Howard F. Jenkinson +5 more
TL;DR: The results demonstrate that the CshA polypeptide is the structural and functional component of S. gordonii adhesive fibrils, and they provide a molecular basis for past correlations of surface fibril production, cell surface hydrophobicity, and adhesion in species of oral "sanguis-like" streptococci.
118