Roderich D. Süssmuth
Technical University of Berlin
319 Papers
2K Citations
Roderich D. Süssmuth is an academic researcher from Technical University of Berlin. The author has contributed to research in topics: Biology & Chemistry. The author has an hindex of 57, co-authored 283 publications. Previous affiliations of Roderich D. Süssmuth include Humboldt University of Berlin & Dresden University of Technology.
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Papers
Pentapeptide repeat protein QnrB1 requires ATP hydrolysis to rejuvenate poisoned gyrase complexes
Łukasz Mazurek,Dmitry Ghilarov,Elizabeth Michalczyk,Zuzanna Pakosz,Mikhail Metelev,Wojciech Czyszczon,Karolina Wawro,Iraj Behroz,Svetlana Dubiley,Roderich D. Süssmuth,Jonathan G. Heddle +10 more
TL;DR: In this article, the authors show that a PRP, QnrB1, provides specific protection against fluoroquinolones, which strictly requires ATP hydrolysis by gyrase.
Biosynthetic gene cluster of the non-ribosomally synthesized cyclodepsipeptide skyllamycin: deciphering unprecedented ways of unusual hydroxylation reactions.
TL;DR: Analysis of the skyllamycin biosynthetic gene cluster revealed the presence of open reading frames encoding proteins for fatty acid precursor biosynthesis, non-ribosomal peptide synthetases, regulators, and transporters along with other modifying enzymes, and specific in-frame mutagenesis of these tailoring enzymes resulted in the production of novel skyLLamycin derivatives.
Site‐Directed Mutagenesis of Putative Active‐Site Residues in Squalene‐Hopene Cyclase
TL;DR: A high content of alpha-helical conformation could be found in the DDTA motif of SHC, providing the first structural information for a triterpene cyclase, and it is proposed that Asp376 and Asp377 are crucial for catalysis and may act as point charges to stabilize intermediate cations.
The gyrase inhibitor albicidin consists of p-aminobenzoic acids and cyanoalanine
Stéphane Cociancich,Alexander Pesic,Daniel Petras,Stefanie Uhlmann,Julian Kretz,Vivien Schubert,Laura Vieweg,Sandrine Duplan,Mélanie Marguerettaz,Julie Noëll,Isabelle Pieretti,Manuela Hügelland,Sebastian Kemper,Andi Mainz,Philippe Rott,Monique Royer,Roderich D. Süssmuth +16 more
TL;DR: The elucidation of the hitherto unknown structure of albicidin is reported, revealing a unique polyaromatic oligopeptide mainly composed of p-aminobenzoic acids that will enable structural investigations on the inhibition mechanism and its assessment as a highly effective antibacterial drug.
Curvopeptin: a new lanthionine-containing class III lantibiotic and its co-substrate promiscuous synthetase.
TL;DR: The discovery and characterization of curvopeptins produced by Thermomonospora curvata, the first class III lantibiotics of thermophilic origin, are described and the surprising promiscuity of the Ser/Thr‐kinase domain is underlined.