Rocio Ramirez-Munoz
Complutense University of Madrid
6 Papers
8 Citations
Rocio Ramirez-Munoz is an academic researcher from Complutense University of Madrid. The author has contributed to research in topics: Effector & T cell. The author has an hindex of 4, co-authored 6 publications.
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Papers
Ultrasensitivity in the Cofilin Signaling Module: A Mechanism for Tuning T Cell Responses
TL;DR: This work proposes that bistability in the cofilin signaling module might be instrumental in T cell responses to antigenic stimulation, and discusses mechanisms that can potentially generate a bistable response in the phosphorylation/dephosphorylation monocycle that regulates the activity of coFilin in dynamic actin networks.
Phosphatase of Regenerating Liver-1 (PRL-1) Regulates Actin Dynamics During Immunological Synapse Assembly and T Cell Effector Function.
Patricia Castro-Sánchez,Rocio Ramirez-Munoz,Noa B. Martín-Cófreces,Oscar Aguilar-Sopeña,Sergio Alegre-Gómez,Sara Hernández-Pérez,Raquel Reyes,Qi Zeng,Carlos Cabañas,Carlos Cabañas,Francisco Sánchez-Madrid,Pedro Roda-Navarro +11 more
TL;DR: Examination of the expression and function of phosphatases of regenerating liver during T cell activation and the dynamic delivery of PRL-1 to the Immunological Synapse provides evidence indicating a regulatory role of PRl-1 during IS assembly, and highlights the involvement ofPRLs in immune responses by mature T cells.
Gene Expression Profiles of Human Phosphotyrosine Phosphatases Consequent to Th1 Polarisation and Effector Function
TL;DR: Changes in gene expression levels suggest a previously nonnoted regulatory role of several PTPs in Th1 polarisation and effector function and a substantial change in the spatial compartmentalisation of ERK during T cell responses is proposed based on changes in the dose of cytoplasmic and nuclear MAPK phosphatases.
Corrigendum to “Gene Expression Profiles of Human Phosphotyrosine Phosphatases Consequent to Th1 Polarisation and Effector Function”
TL;DR: This research presents a novel probabilistic approach to estimating the response of the immune system to laser-spot assisted, 3D image analysis of central nervous system injury.
Regulation of CD4+ T Cell Signaling and Immunological Synapse by Protein Tyrosine Phosphatases: Molecular Mechanisms in Autoimmunity
Patricia Castro-Sánchez,Oscar Aguilar-Sopeña,Sergio Alegre-Gómez,Rocio Ramirez-Munoz,Pedro Roda-Navarro +4 more
TL;DR: The current knowledge about the regulatory role of PTPs in CD4+ T cell activation, IS assembly and effector function is reviewed and the potential molecular mechanisms mediating the action of these enzymes in autoimmune disorders are discussed.