Robyn Labrum
University College London
28 Papers
76 Citations
Robyn Labrum is an academic researcher from University College London. The author has contributed to research in topics: Ataxia & Spinocerebellar ataxia. The author has an hindex of 15, co-authored 25 publications. Previous affiliations of Robyn Labrum include UCL Institute of Neurology & University College Hospital.
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Papers
Long-term disease progression in spinocerebellar ataxia types 1, 2, 3, and 6: a longitudinal cohort study
Heike Jacobi,Sophie Tezenas du Montcel,Peter Bauer,Paola Giunti,Arron Cook,Robyn Labrum,Michael H Parkinson,Alexandra Durr,Alexis Brice,Perrine Charles,Cecilia Marelli,Caterina Mariotti,Lorenzo Nanetti,Marta Panzeri,Maria Rakowicz,Anna Sulek,Anna Sobanska,Tanja Schmitz-Hübsch,Ludger Schöls,Ludger Schöls,Holger Hengel,Holger Hengel,Laszlo Baliko,Béla Melegh,Alessandro Filla,Antonella Antenora,Jon Infante,José Berciano,Bart P.C. van de Warrenburg,Dagmar Timmann,Sandra Szymanski,Sylvia Boesch,Jun Suk Kang,Massimo Pandolfo,Jörg B. Schulz,Sonia Molho,Alhassane Diallo,Thomas Klockgether,Thomas Klockgether +38 more
TL;DR: This study provides quantitative data on the progression of the most common spinocerebellar ataxias based on a follow-up period that exceeds those of previous studies and could prove useful for sample size calculation and patient stratification in interventional trials.
250
Dravet syndrome as epileptic encephalopathy: evidence from long-term course and neuropathology
Claudia B. Catarino,Joan Liu,Ioannis Liagkouras,Vaneesha Gibbons,Robyn Labrum,Rachael Ellis,Cathy E. Woodward,Mary B. Davis,Shelagh J.M. Smith,J. Helen Cross,J. Helen Cross,Richard Appleton,Simone C. Yendle,Jacinta M McMahon,Susannah T. Bellows,Thomas S. Jacques,Thomas S. Jacques,Sameer M. Zuberi,Matthias J. Koepp,Lillian Martinian,Ingrid E. Scheffer,Ingrid E. Scheffer,Maria Thom,Sanjay M. Sisodiya +23 more
TL;DR: Evidence is provided that Dravet syndrome is at least in part an epileptic encephalopathy, and there was remarkable preservation of neurons and interneurons in the neocortex and hippocampi of DraveT adult post-mortem cases.
Responsiveness of different rating instruments in spinocerebellar ataxia patients.
T. Schmitz-Hübsch,Rolf Fimmers,Maryla Rakowicz,Rafał Rola,E. Zdzienicka,Roberto Fancellu,Christian Mariotti,Christoph Linnemann,Ludger Schöls,Dagmar Timmann,A. Filla,Elena Salvatore,Jon Infante,Paola Giunti,Robyn Labrum,Berry Kremer,B.P.C. van de Warrenburg,L. Baliko,Béla Melegh,Chantal Depondt,Jörg B. Schulz,S. Tezenas du Montcel,Thomas Klockgether +22 more
TL;DR: The EQ-5D visual analogue scale proved insufficient for longitudinal assessment, but validly reflected patients' impression of change, and the clinical relevance of SCAFI and 9-hole pegboard score changes warrants further exploration.
173
Survival in patients with spinocerebellar ataxia types 1, 2, 3, and 6 (EUROSCA): a longitudinal cohort study.
Alhassane Diallo,Heike Jacobi,Arron Cook,Robyn Labrum,Alexandra Durr,Alexis Brice,Perrine Charles,Cecilia Marelli,Caterina Mariotti,Lorenzo Nanetti,Marta Panzeri,Maria Rakowicz,Anna Sobanska,Anna Sulek,Tanja Schmitz-Hübsch,Tanja Schmitz-Hübsch,Ludger Schöls,Holger Hengel,Béla Melegh,Alessandro Filla,Antonella Antenora,Jon Infante,José Berciano,Bart P.C. van de Warrenburg,Dagmar Timmann,Sylvia Boesch,Massimo Pandolfo,Jörg B. Schulz,Peter Bauer,Paola Giunti,Jun Suk Kang,Thomas Klockgether,Thomas Klockgether,Sophie Tezenas du Montcel +33 more
TL;DR: The results have implications for the design of future interventional studies of spinocerebellar ataxias; for example, the prognostic survival nomogram could be useful for selection and stratification of patients.
Long-term evolution of patient-reported outcome measures in spinocerebellar ataxias.
Heike Jacobi,Heike Jacobi,Sophie Tezenas du Montcel,Peter Bauer,Paola Giunti,Arron Cook,Robyn Labrum,Michael H Parkinson,Alexandra Durr,Alexis Brice,Perrine Charles,Cecila Marelli,Caterina Mariotti,Lorenzo Nanetti,Lidia Sarro,Maria Rakowicz,Anna Sulek,Anna Sobanska,Tanja Schmitz-Hübsch,Ludger Schöls,Holger Hengel,Laszlo Baliko,Béla Melegh,Alessandro Filla,Antonella Antenora,Jon Infante,José Berciano,Bart P.C. van de Warrenburg,Dagmar Timmann,Sandra Szymanski,Sylvia Boesch,Wolfgang Nachbauer,Jun Suk Kang,Massimo Pandolfo,Jörg B. Schulz,Audrey Tanguy Melac,Alhassane Diallo,Thomas Klockgether,Thomas Klockgether +38 more
TL;DR: In the common SCAs, PROMs give complementary information to the information provided by neurological scales and underlines the importance of PRoms as additional outcome measures in future interventional trials.