https://www.cidjournal.com/article/S0738-081X(98)00008-X/pdf

Drug-Induced Pemphigoid:: Bullous and Cicatricial

Patients with psoriasis are frequently complicated with autoimmune bullous diseases, especially, pemphigoid diseases. It has been known that one-third cases of anti-laminin gamma1 pemphigoid, formerly anti-p200 pemphigoid, are associated with psoriasis whereas bullous pemphigoid is the most frequently associated bullous disease in psoriasis cases regardless of the lack of detectable levels of the accompanying anti-laminin gamma1 autoantibodies. Despite several suggestions, however, the definitive reason of the striking association of psoriasis and these autoimmune bullous diseases remains elusive. In this review, we look over the epidemiological evidence of the association of psoriasis and autoimmune bullous diseases and the information of genetic susceptibilities of each disease, and discuss the possible mechanisms of their complication with reference to the recent understandings of each pathogenesis.

/pdf/interaction-of-psoriasis-and-bullous-diseases-jiz5zt9god.pdf

Interaction of Psoriasis and Bullous Diseases.

Absence of anti-Ro and anti-La antibodies in pemphigus and pemphigoid sera

A 69-year-old male with CRF due to DM developed PV. This patient suddenly developed bullas and erosions on his arms and thighs which spread to his trunk, neck, limbs, hands and feet after a 4-year history of PV. Our diagnosis was PV coexisting with BP from the results of a skin biopsy and the results of anti-BP 180 and 230 antibodies detection. We started the systemic administration of steroid tablets, but we did not elect immunosuppressive therapies (cyclosporine and methotrexate) because of his hypertension and the risk of malignancy. The treatment of the patient’s DM was modified from oral medicine to insulin injections. After three weeks of treatment, his laboratory results showed the eosinophilia (41.3%), and we increased the dose of steroids (betamethazone 2 mg/day) and anti-histamine tablets. After the 1.5 months of his hospitalization, his cutaneous condition and eosinophilia improved. There could be as many as 100 cases of PV coexisting with BP, and this is a rare case of PV complicated with BP and eosinophilia.

A Case of Psoriasis Vulgaris Coexisting with Bullous Pemphigoid and Eosinophilia in a 69-year-old Male with Diabetes Mellitus and Chronic Renal Failure

Various exogenous factors (eg, drugs, dietary antigens, trauma, infections, radiographs, and UV radiation) are known to induce or aggravate skin diseases. UV radiation in particular is known to induce or aggravate the autoimmune bullous diseases of pemphigus foliaceus, pemphigus vulgaris, and bullous pemphigoid. Its role in linear IgA dermatosis, however, is not well recognized. We report the second case of linear IgA dermatosis induced by intense sun exposure in which blistering was induced by UVA radiation. Furthermore, a review of the literature on photoinduced autoimmune bullous diseases and the wavelengths responsible for the induction of blistering is presented and several proposed mechanisms of action for the blister induction, including release or unmasking of antigens, promotion of antibody fixation by UV radiation, and launching of an inflammatory process, are discussed. We conclude that linear IgA dermatosis should be added to the list of autoimmune bullous diseases induced and/or aggravated by UV radiation.

UV light-induced linear IgA dermatosis.

Bullous pemphigoid and psoriasis

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Bullous pemphigoid and psoriasis