Robin V. Ward
Heidelberg University
13 Papers
140 Citations
Robin V. Ward is an academic researcher from Heidelberg University. The author has contributed to research in topics: Presenilin & Cleavage (embryo). The author has an hindex of 8, co-authored 13 publications.
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Papers
Common structural features determine the effectiveness of carvedilol, daunomycin and rolitetracycline as inhibitors of Alzheimer beta-amyloid fibril formation.
TL;DR: Molecular modelling data suggest that a series of tetracyclic and carbazole-type compounds used as inhibitors of Abeta fibril formation have in common the ability to adopt a specific three-dimensional pharmacophore conformation that might be essential for binding to Abeta and preventing it from forming fibrils.
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Expression, purification, and functional analysis of the human serine protease HtrA2.
John Savopoulos,Paul S. Carter,Sandra Turconi,Gary Pettman,Eric Karran,Carol W. Gray,Robin V. Ward,Owen Jenkins,Caretha L. Creasy +8 more
TL;DR: It was found that molecular analysis of processing events in Sf9 cells allowed us to revisit E. coli expression systems which were initially unsuccessful and produce milligram amounts of >90% pure recombinant enzyme as determined by SDS-PAGE gels.
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Proteolytic fragments of Alzheimer's disease-associated presenilin 1 are present in synaptic organelles and growth cone membranes of rat brain
Dirk Beher,Christine Elle,John R. Underwood,John B. Davis,Robin V. Ward,Eric Karran,Colin L. Masters,Konrad Beyreuther,Gerd Multhaup +8 more
TL;DR: Results indicate that rat brain presenilin 1 fragments exit from these biosynthetic compartments to reach synaptic organelles in neurons, in contrast to a predominant subcellular localization of presenILin 1 to the endoplasmic reticulum and Golgi apparatus.
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Alzheimer's Disease:correlation of the suppression of β-Amyloid peptide secretion from cultured cells with inhibition of the chymotrypsin-like activity of the proteasome
Gary Christie,R. Markwell,Carol W. Gray,L. Smith,F. Godfrey,F. Mansfield,H. Wadsworth,Rodney A. King,Michael R. McLaughlin,D. G. Cooper,Robin V. Ward,D. R. Howlett,Tobias Hartmann,Stefan F. Lichtenthaler,Konrad Beyreuther,John R. Underwood,S. K. Gribble,Roberto Cappai,Colin L. Masters,A. Tamaoka,R. L. Gardner,A. J. Rivett,Eric Karran,David Allsop +23 more
TL;DR: It is found that the ability of the peptide aldehyde and boronate inhibitors to suppress Aβ formation from cells correlated extremely well with their potency as CLIP inhibitors, concluding that the proteasome may be involved either directly or indirectly in A β formation.
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Presenilin–1 is Processed into Two Major Cleavage Products in Neuronal Cell Lines
Robin V. Ward,John B. Davis,Carol W. Gray,Amanda J. L. Barton,Laura G. Bresciani,Matilde Caivano,Vivienne F. Murphy,Karen Duff,Mike Hutton,John Hardy,G.W. Roberts,Eric Karran +11 more
TL;DR: Presenilin-1 has been identified as the protein encoded by the chromosome 14 locus that, when mutated, leads to familial Alzheimer's disease (FAD), and it is demonstrated by immunodetection that PS-1 is processed to give two fragments: an N-terminal 28 kDa fragment, and a C-Terminal 18 kDa fragments.
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