Robin Stipp
4 Papers
Robin Stipp is an academic researcher. The author has contributed to research in topics: Biology & Ligand (biochemistry). The author has an hindex of 2, co-authored 3 publications.
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Papers
Lysosomal GPCR-like protein LYCHOS signals cholesterol sufficiency to mTORC1
Hijai R. Shin,Y. Rose Citron,Lei Wang,Laura Tribouillard,Claire Goul,Robin Stipp,Yusuke Sugasawa,Aakriti Jain,Nolwenn Samson,Chun-Yan Lim,Oliver B. Davis,David Castaneda-Carpio,Ming-Yi Qian,Daniel K. Nomura,Rushika M. Perera,Eun Young Park,Douglas F. Covey,Mathieu Laplante,Alex S. Evers,Roberto Zoncu +19 more
TL;DR: This work has identified LYCHOS, a multidomain transmembrane protein that enables cholesterol-dependent activation of the master growth regulator, the protein kinase mechanistic Target of Rapamycin Complex 1 (mTORC1).
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Watching the release of a photopharmacological drug from tubulin using time-resolved serial crystallography
M. Wranik,Tobias Weinert,C. Slavov,Tiziana Masini,Antonia Furrer,Natacha Gaillard,D. Gioia,Marco Ferrarotti,Daniel James,Hannah Glover,Melissa Carrillo,Demet Kekilli,Robin Stipp,Petr Skopintsev,Steffen Brünle,Tobias Mühlethaler,John H. Beale,Dardan Gashi,Karol Nass,Dmitry Ozerov,P. Johnson,Claudio Cirelli,Camila Bacellar,Markus Braun,Meitian Wang,Florian S. N. Dworkowski,Christopher George Milne,Andrea Cavalli,Josef Wachtveitl,Michel O. Steinmetz,Jörg Standfuss +30 more
TL;DR: In this article , the authors used time-resolved serial crystallography at a synchrotron and X-ray free-electron laser to capture the release of the anti-cancer compound azo-combretastatin A4 and the resulting conformational changes in tubulin.
A multi-reservoir extruder for time-resolved serial protein crystallography and compound screening at X-ray free-electron lasers
M. Wranik,Michal W Kepa,Emma V. Beale,Daniel James,Quentin Bertrand,Tobias Weinert,Antonia Furrer,Hannah Glover,Dardan Gashi,Melissa Carrillo,Yasushi Kondo,Robin Stipp,Georgii Khusainov,Karol Nass,Dmitry Ozerov,C. Cirelli,P. Johnson,Florian S. N. Dworkowski,John H Beale,Scott Stubbs,Thierry Zamofing,Marco Schneider,Kristina Krauskopf,Li Gao,Oliver Thorn-Seshold,Christoph Bostedt,Camila Bacellar,Michel O Steinmetz,Christopher George Milne,Jörg Standfuss +29 more
TL;DR: Researchers developed a multi-reservoir extruder for efficient sample delivery at X-ray free-electron lasers, reducing sample exchange time and user workload, enabling time-resolved protein structure determination and compound screening with minimal data.
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Molecular snapshots of drug release from tubulin over eleven orders of magnitude in time
Maximillian Wranik,Tobias Weinert,C. Slavov,Tiziana Masini,Antonia Furrer,Natacha Gaillard,D. Gioia,Marco Ferrarotti,Daniel James,Hannah Glover,Melissa Carrillo,Demet Kekilli,Robin Stipp,Petr Skopintsev,Steffen Brünle,Tobias Mühlethaler,John H. Beale,Dardan Gashi,Karol Nass,Dmitry Ozerov,P. Johnson,Claudio Cirelli,Camila Bacellar,Markus Braun,Meitian Wang,Florian S. N. Dworkowski,Christopher George Milne,Andrea Cavalli,Josef Wachtveitl,Michel O. Steinmetz,Jörg Standfuss +30 more
- 17 Feb 2022
TL;DR: Time-resolved serial crystallography reveals structural changes in tubulin upon release of a photoswitchable microtubule inhibitor.