Robin Pieterman
2 Papers
Robin Pieterman is an academic researcher. The author has contributed to research in topics: Translocator protein & Inflammation. The author has an hindex of 1, co-authored 1 publications.
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Papers
Translocator protein is a marker of activated microglia in rodent models but not human neurodegenerative diseases
Erik Nutma,Nurun Nahar Fancy,Maria Weinert,Stergios Tsartsalis,Manuel C. Marzin,Robert C. Muirhead,Irene Falk,Marjolein Breur,Joy de Bruin,David Hollaus,Robin Pieterman,Jasper J. Anink,David Story,Siddharthan Chandran,Jiabin Tang,Maria Chiara Trolese,Takashi Saito,Takaomi C. Saido,Katharine H. Wiltshire,Paula Beltran-Lobo,Alexandra Phillips,Jack P. Antel,Luke M. Healy,Marie-France Dorion,Dylan A. Galloway,Rochelle Y. Benoit,Quentin Amossé,Kelly Ceyzériat,Aurélien M. Badina,E. Kövari,Caterina Bendotti,Eleonora Aronica,Carola I. Radulescu,Jia Hui Wong,Anna M. Barron,Amy M. Smith,Samuel J. Barnes,David W. Hampton,P. Ven Der Valk,Steven Jacobson,Owain W. Howell,David Baker,Markus Kipp,Hannes Kaddatz,Benjamin B. Tournier,Philippe Millet,Paul M. Matthews,Craig S. Moore,Sandra Amor,David R. Owen +49 more
TL;DR: It is shown that TSPO expression increases in activated microglia in mouse brain disease models but does not change in a non-human primate disease model or in common neurodegenerative and neuroinflammatory human diseases, and that T SPO-PET signals in humans reflect the density of inflammatory cells rather than activation state.
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Translocator protein is a marker of activated microglia in rodent models but not human neurodegenerative diseases
Erik Nutma,Nurun Nahar Fancy,Maria Weinert,Manuel C. Marzin,Stergios Tsartsalis,Robert C. Muirhead,Irene Falk,Joy de Bruin,David Hollaus,Robin Pieterman,Jasper J. Anink,David Story,Siddharthan Chandran,Jiabin Tang,Maria Chiara Trolese,Takashi Saito,Takaomi C. Saido,Katie Wiltshire,Paula Beltran-Lobo,Alexandra Philips,Jack P. Antel,Luke M. Healy,Craig S. Moore,Caterina Bendotti,Eleonora Aronica,Carola I. Radulescu,Samuel J. Barnes,David W. Hampton,P. Ven Der Valk,Steven Jacobson,Paul M. Matthews,Sandra Amor,David R. Owen +32 more
TL;DR: It is shown that TSPO expression in human myeloid cells is related to different phenomena than in mice, and that T SPO PET reflects density of inflammatory cells rather than activation state, and is mechanistically linked to classical pro-inflammatory myeloids cell function in rodents but not humans.