Roberto Tirabosco
Royal National Orthopaedic Hospital
125 Papers
251 Citations
Roberto Tirabosco is an academic researcher from Royal National Orthopaedic Hospital. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 42, co-authored 110 publications.
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Papers
MicroRNA profiling of peripheral nerve sheath tumours identifies miR-29c as a tumour suppressor gene involved in tumour progression.
Nadege Presneau,Malihe Eskandarpour,T Shemais,Stephen Henderson,Dina Halai,Roberto Tirabosco,Adrienne M. Flanagan +6 more
TL;DR: Evidence is provided that reduction of miR-29c has a pivotal role in the progression of nerve sheath tumour progression and results by increasing the invasive/migratory properties of nerveSheath tumours.
Nonbacterial osteitis: a clinical, histopathological, and imaging study with a proposal for protocol-based management of patients with this diagnosis
Panagiotis D. Gikas,Lily Islam,William Aston,Roberto Tirabosco,Asif Saifuddin,Timothy W. R. Briggs,Steve Cannon,Paul O'Donnell,Benjamin Jacobs,Adrienne M. Flanagan,Adrienne M. Flanagan +10 more
TL;DR: A retrospective clinical, histopathological, and radiological study of 41 children diagnosed with nonbacterial osteitis, finding that improving knowledge of the presenting signs and symptoms and related disorders, rationalizing the therapeutic approach, and allowing us to learn about the natural history of the disease are predicted.
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Activating mutations in the MAP-kinase pathway define non-ossifying fibroma of bone.
Daniel Baumhoer,Michal Kovac,Jan Sperveslage,Baptiste Ameline,Anna-Christina Strobl,Arthur Krause,Marcel Trautmann,Eva Wardelmann,Michaela Nathrath,Sylvia Höller,Jendrik Hardes,Georg Gosheger,Andreas H. Krieg,Volker Vieth,Roberto Tirabosco,Fernanda Amary,Adrienne M. Flanagan,Wolfgang Hartmann +17 more
TL;DR: This study adds another benign lesion to the spectrum of KRAS‐ and MAP‐kinase signalling‐driven tumours by identifying hotspot KRAS, FGFR1 and NF1 mutations in patients with non‐ossifying fibroma.
Sensitivity of MDM2 amplification and unexpected multiple faint alphoid 12 (alpha 12 satellite sequences) signals in atypical lipomatous tumor
Takeshi Kashima,Dina Halai,Hongtao Ye,Sandra Nalini Hing,David Delaney,Robin Pollock,Paul O'Donnell,Roberto Tirabosco,Adrienne M. Flanagan +8 more
TL;DR: This study assessed whether analysis of MDM2 copy number by fluorescence in situ hybridization (FISH) would help distinguish lipomas from atypical lipomatous tumors, otherwise referred to as well-differentiated liposarcomas, using a commercially availableMDM2 FISH kit.
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Fibroblastic growth factor receptor 1 amplification in osteosarcoma is associated with poor response to neo-adjuvant chemotherapy
M Fernanda Amary,Hongtao Ye,Fitim Berisha,Bhavisha Khatri,Georgina Forbes,Katie Lehovsky,Anna Maria Frezza,Sam Behjati,Patrick S. Tarpey,Nischalan Pillay,Peter J. Campbell,Roberto Tirabosco,Nadege Presneau,Sandra J. Strauss,Adrienne M. Flanagan +14 more
TL;DR: This study provides a rationale for inclusion of patients with osteosarcoma in clinical trials using FGFR kinase inhibitors by determining if this biomarker could be used for stratification of patients for treatment.
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