Roberto Tirabosco
Royal National Orthopaedic Hospital
125 Papers
251 Citations
Roberto Tirabosco is an academic researcher from Royal National Orthopaedic Hospital. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 42, co-authored 110 publications.
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Papers
Destructive Synovial Hemangioma of the Hip Resembling Pigmented Villonodular Synovitis
Nicholas S. Kalson,Panagiotis D. Gikas,Roberto Tirabosco,Paul O'Donnell,John A. Skinner,Adrienne M. Flanagan +5 more
TL;DR: A case of synovial hemangioma of the hip causing joint destruction severe enough to warrant arthroplasty in a 32-year-old man who presented with a 2-year history of hip pain and worsening limp is reported.
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Circulating tumour DNA is a promising biomarker for risk stratification of central chondrosarcoma with IDH1/2 and GNAS mutations.
Iben Lyskjaer,Christopher Davies,Christopher Davies,Anna-Christina Strobl,Anna-Christina Strobl,Joanna Hindley,Steven James,Radhesh K Lalam,William Cross,Geoff Hide,Kenneth S. Rankin,Kenneth S. Rankin,Lee Jeys,Roberto Tirabosco,Jonathan Stevenson,Paul O'Donnell,Paul O'Donnell,Paul Cool,Paul Cool,Adrienne M. Flanagan,Adrienne M. Flanagan +20 more
TL;DR: In this paper, the level of circulating tumour DNA (ctDNA) in the blood of chondrosarcoma patients could be used to predict outcome, and the results are promising, they are based on a small number of patients, and therefore, introduction of this blood test into clinical practice as a complementary assay to current standard-of-care protocols would allow the assay to be assessed more stringently and developed for the treatment of patients with CS.
4
Epigenetic inactivation of oncogenic brachyury (TBXT) by H3K27 histone demethylase controls chordoma cell survival
Lucia Cottone,Edward Hookway,Adam P. Cribbs,Graham Wells,Patrick Lombard,Lorena Ligammari,Anthony Tumber,Roberto Tirabosco,Fernanda Amary,T. Szommer,Catrine Johannson,Paul Brennan,Nischalan Pillay,U. Oppermann,Adrienne M. Flanagan +14 more
TL;DR: Previous data showing that the function of TBXT is essential for maintaining notochord cell fate and function are supported and the data suggest that TBXT can potentially be targeted therapeutically by modulating epigenetic control mechanisms such as H3K27 demethylases are suggested.
Ossifying fibromyxoid tumour, an unusual cause of rim ossification: Imaging features and correlation with histopathology
TL;DR: It is demonstrated that some benign imaging features may relate to a lesion with histology that has a less predictable clinical outcome, dependant on correct initial management.
3
EWSR1-SMAD3 fibroblastic tumour of bone: expanding the clinical spectrum
Solange De Noon,Adrienne M. Flanagan,Adrienne M. Flanagan,Roberto Tirabosco,Paul O'Donnell,Paul O'Donnell,Fernanda Amary,Fernanda Amary +7 more
TL;DR: The radiological and histological features of the first reported occurrence of this entity in bone: a 44-year-old man with a tumour in the right tibia, treated with en bloc resection and showing no signs of relapse at 7 years are presented.