Roberto Tirabosco
Royal National Orthopaedic Hospital
125 Papers
251 Citations
Roberto Tirabosco is an academic researcher from Royal National Orthopaedic Hospital. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 42, co-authored 110 publications.
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Papers
Post-translational regulation contributes to the loss of LKB1 expression through SIRT1 deacetylase in osteosarcomas
Nadege Presneau,Laure Alice Duhamel,Hongtao Ye,Roberto Tirabosco,Adrienne M. Flanagan,Malihe Eskandarpour +5 more
TL;DR: Investigations revealed the involvement of sequential regulation of miR-204/SIRT1/LKB1 in the regulation of SIRT1 expression, which impairs LKB1 stability and showed a mechanism for the loss of expression of L KB1 tumour suppressor in this malignancy.
Clear cell sarcoma of the mediastinum.
Roberto Tirabosco,Loic Lang-Lazdunski,Timothy C. Diss,Maria Fernanda Amary,Maria Fernanda Amary,Manuel Rodriguez-Justo,David Landau,Will Lorenzi,Adrienne M. Flanagan,Adrienne M. Flanagan,Adrienne M. Flanagan +10 more
TL;DR: The diagnosis of clear cell sarcoma was supported by demonstrating the presence of an EWS gene rearrangement by fluorescence in situ hybridization and there was no evidence that this lesion represented metastatic disease.
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Clinical outcome in patients with peripherally-sited atypical lipomatous tumours and dedifferentiated liposarcoma.
Sangeetha N Kalimuthu,Charles Tilley,Georgina Forbes,Hongtao Ye,Katie Lehovsky,Nischalan Pillay,Beatrice Seddon,Beatrice Seddon,Paul O'Donnell,Robin Pollock,Roberto Tirabosco,M Fernanda Amary,Adrienne M. Flanagan +12 more
- 16 Mar 2015
TL;DR: Extending the study period revealed that atypical lipomatous tumour could recur up to 40 years after the first surgery, and it is recommended that, following post‐operative wound care, patients with atypicals lipomAtous tumours are referred back to their general practitioner for follow up, but that in the event of a suspected recurrence they have rapid access back to the specialist unit using a ‘supported discharge’ scheme.
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Metastatic pulmonary intimal sarcoma presenting as cauda equina syndrome: first report of a case.
TL;DR: This is the first case of metastatic pulmonary intimal sarcoma presenting as cauda equine syndrome described in the literature, and the patient went on to receive a more formal vertebrectomy, front and back repair, and radiotherapy.
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Primary myxoid liposarcoma of the ovary in an adolescent girl: a case report.
TL;DR: Primary ovarian myxoid liposarcoma has not been previously reported in the English literature and the morphologic appearances were supported by the presence of the rearrange of the CHOP gene demonstrated by interphase fluorescent in situ hybridization.
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