Roberto Puzone
National Cancer Research Institute
22 Papers
243 Citations
Roberto Puzone is an academic researcher from National Cancer Research Institute. The author has contributed to research in topics: Immune system & Epitope. The author has an hindex of 12, co-authored 20 publications.
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Papers
Narrowed TCR repertoire and viral escape as a consequence of heterologous immunity
Markus Cornberg,Alex T. Chen,Lee A. Wilkinson,Michael A. Brehm,Sung-Kwon Kim,Claudia Calcagno,Dario Ghersi,Roberto Puzone,Franco Celada,Franco Celada,Raymond M. Welsh,Liisa K. Selin +11 more
TL;DR: T cell oligoclonality, including extremes in clonal dominance, may be a consequence of heterologous immunity and lead to viral escape, which has implications for the design of peptide-based vaccines, which might unintentionally prime for skewed TCR responses to cross-reactive epitopes.
Narrowed TCR repertoire and viral escape as a consequence of heterologous immunity.
Markus Cornberg,Alex T Chen,Lee A Wilkinson,Michael A. Brehm,Sung-Kwon Kim,Claudia Calcagno,Dario Ghersi,Roberto Puzone,Franco Celada,Raymond M Welsh,Liisa K. Selin +10 more
TL;DR: T cell oligoclonality, including extremes in clonal dominance, may be a consequence of heterologous immunity and lead to viral escape, which has implications for the design of peptide-based vaccines, which might unintentionally prime for skewed TCR responses to cross-reactive epitopes.
131
IFN-Induced Attrition of CD8 T Cells in the Presence or Absence of Cognate Antigen during the Early Stages of Viral Infections
Kapil Bahl,Sung-Kwon Kim,Claudia Calcagno,Claudia Calcagno,Dario Ghersi,Roberto Puzone,Franco Celada,Franco Celada,Liisa K. Selin,Raymond M. Welsh +9 more
TL;DR: Results indicate that Ag engagement does not protect CD8 T cells from the IFN-induced T cell attrition associated with viral infections, and computer models indicated that early depletion of memory T cells may allow for the generation for a more diverse T cell response to infection by reducing the immunodomination caused by cross-reactive T cells.
126
A systematic approach to vaccine complexity using an automaton model of the cellular and humoral immune system. I. Viral characteristics and polarized responses.
TL;DR: In this article, the authors used IMMSIM3, a cellular automaton model for simulating humoral and cell-mediated responses, to explore a wide range of virus-host relations.
79
Heterologous immunity: immunopathology, autoimmunity and protection during viral infections.
Liisa K. Selin,Myriam F. Wlodarczyk,Anke R. M. Kraft,Siwei Nie,Laurie L. Kenney,Roberto Puzone,Franco Celada +6 more
TL;DR: In this paper, the authors review the evidence that to better understand these autoreactive pathologies it requires an evaluation of how T cells are regulated and evolve during sequential infections with different pathogens under the influence of heterologous immunity.