Roberto Narcisi
Erasmus University Rotterdam
50 Papers
57 Citations
Roberto Narcisi is an academic researcher from Erasmus University Rotterdam. The author has contributed to research in topics: Mesenchymal stem cell & Chondrogenesis. The author has an hindex of 12, co-authored 38 publications. Previous affiliations of Roberto Narcisi include University Medical Center.
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Papers
Long-Term Expansion, Enhanced Chondrogenic Potential, and Suppression of Endochondral Ossification of Adult Human MSCs via WNT Signaling Modulation
Roberto Narcisi,Mairéad A. Cleary,Mairéad A. Cleary,Pieter A.J. Brama,Martin J. Hoogduijn,Nesrin Tüysüz,Derk ten Berge,Gerjo J.V.M. van Osch +7 more
TL;DR: It is reported that the signaling protein WNT3A, in combination with FGF2, supports long-term expansion of human bone marrow-derived MSCs and it is discovered that endogenous WNT signals are the main drivers of the hypertrophic maturation that follows chondrogenic differentiation.
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Expression of CD105 on expanded mesenchymal stem cells does not predict their chondrogenic potential.
Mairéad A. Cleary,Mairéad A. Cleary,Roberto Narcisi,K. Focke,R. Van der Linden,Pieter A.J. Brama,G.J.V.M. van Osch +6 more
TL;DR: It is demonstrated that CD105 expression on culture expanded BMSC populations does not associate with a chondroprogenitor phenotype and CD105 should not be pursued as a marker to obtain a chondingrogenic population from BMSCs.
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FGF, TGFβ and Wnt crosstalk: embryonic to in vitro cartilage development from mesenchymal stem cells
Mairéad A. Cleary,Mairéad A. Cleary,Gerjo J.V.M. van Osch,Pieter A.J. Brama,Catharine A. Hellingman,Roberto Narcisi +5 more
TL;DR: Current knowledge on the crosstalk between the FGF, TGFβ and Wnt signalling pathways during different stages of mesenchymal chondrogenesis is defined to provide insights into how to improve and progress cartilage tissue engineering for the future.
60
Silencing of Antichondrogenic MicroRNA-221 in Human Mesenchymal Stem Cells Promotes Cartilage Repair In Vivo.
Andrea Lolli,Roberto Narcisi,Elisabetta Lambertini,Letizia Penolazzi,Marco Angelozzi,Nicole Kops,Simona Gasparini,Gerjo J.V.M. van Osch,Roberta Piva +8 more
TL;DR: The data indicate that silencing miR‐221 has a prochondrogenic role in vivo, opening new possibilities for the use of hMSCs in cartilage tissue engineering.
Collagen type X is essential for successful mesenchymal stem cell-mediated cartilage formation and subsequent endochondral ossification.
Callie Knuth,E. Andrés Sastre,Niamh Fahy,Janneke Witte-Bouma,Yanto Ridwan,E M Strabbing,M J Koudstaal,J van de Peppel,Eppo B. Wolvius,Roberto Narcisi,Eric Farrell +10 more
TL;DR: The present study investigated the importance of COLX by shRNA-mediated gene silencing in primary MSCs and found that a significant knock-down ofCOLX disrupted the production of extracellular matrix key components and the secretion profile of chondrogenically differentiated MSCS.