Roberta Mancinelli
Cedars-Sinai Medical Center
5 Papers
136 Citations
Roberta Mancinelli is an academic researcher from Cedars-Sinai Medical Center. The author has contributed to research in topics: TLR4 & Lipopolysaccharide. The author has an hindex of 4, co-authored 5 publications.
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Papers
Differential expression and regulation of toll-like receptors (TLR) in human leukocytes: selective expression of TLR3 in dendritic cells.
Marta Muzio,Daniela Bosisio,Nadia Polentarutti,Giovanna D'Amico,Antonella Stoppacciaro,Roberta Mancinelli,C. van 't Veer,Giselle Pentón-Rol,Luigi Ruco,Paola Allavena,Alberto Mantovani +10 more
TL;DR: It is demonstrated that TLR1 through TLR5 mRNAs are differentially expressed and regulated in human leukocytes, and that expression of TLR3 transcripts is restricted to DC that are the only elements which express the full TLR repertoire.
•Journal Article
Selective inhibition of expression of the chemokine receptor CCR2 in human monocytes by IFN-gamma
Giselle Pentón-Rol,Nadia Polentarutti,Walter Luini,Alessandro Borsatti,Roberta Mancinelli,Antonio Sica,Silvano Sozzani,Alberto Mantovani +7 more
TL;DR: IFN-gamma selectively and rapidly inhibited expression of the monocyte chemotactic protein (MCP) receptor CCR2 with an ED50 of approximately 50 U/ml, consistent with an emerging paradigm of divergent regulation by several agents of chemokine production and receptor expression in monocytes.
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•Journal Article
Expression of monocyte chemotactic protein-3 in human monocytes and endothelial cells.
Nadia Polentarutti,Martino Introna,Silvano Sozzani,Roberta Mancinelli,Giovanna Mantovani,Alberto Mantovani +5 more
TL;DR: EC-produced MCP-3 may be important in the regulation of extravasation of receptor-expressing cells, including NK cells and eosinophils and its regulation by pro- and anti-inflammatory cytokines.
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Bacterial Lipopolysaccharide (LPS) Activates NF-κB through Interleukin-1 (IL-1) Signaling Mediators in Cultured Human Endothelial Cells and Mononuclear Phagocytes
Frank X. Zhang,Carsten J Kirschning,Roberta Mancinelli,Emmanuelle Faure,Alberto Mantovani,Mike Rothe,Marta Muzio,Moshe Arditi +7 more
TL;DR: Bacterial Lipopolysaccharide Activates NF-κB through Interleukin-1 (IL-1) Signaling Mediators in Cultured Human Endothelial Cells and Mononuclear Phagocytes.
Bacterial Lipopolysaccharide Activates Nuclear Factor-κB through Interleukin-1 Signaling Mediators in Cultured Human Dermal Endothelial Cells and Mononuclear Phagocytes
Frank X. Zhang,Carsten J. Kirschning,Roberta Mancinelli,Xiao-Ping Xu,Yiping Jin,Emmanuelle Faure,Alberto Mantovani,Mike Rothe,Marta Muzio,Moshe Arditi +9 more
TL;DR: Investigation of the role and involvement of interleukin-1 (IL-1) and tumor necrosis factor (TNF-α) signal transducer molecules in LPS signaling in human dermal microvessel endothelial cells (HDMEC) and THP-1 monocytic cells suggests that a signal transduction molecule in the LPS receptor complex may belong to the IL-1 receptor/toll-like receptor (TLR) super family.