Robert Yakulis
Allegheny General Hospital
5 Papers
165 Citations
Robert Yakulis is an academic researcher from Allegheny General Hospital. The author has contributed to research in topics: Cancer & Aneuploidy. The author has an hindex of 5, co-authored 5 publications.
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Papers
U.S. Case Report of Cerebral Phaeohyphomycosis Caused by Ramichloridium obovoideum (R. mackenziei): Criteria for Identification, Therapy, and Review of Other Known Dematiaceous Neurotropic Taxa
TL;DR: A case of cerebral phaeohyphomycosis in a 36-year-old male caused by the neurotropic fungus Ramichloridium obovoideum (Matushima) de Hoog 1977 is reported to alert clinicians and personnel in clinical mycology laboratories of the pathogenicity of this organism and its potential occurrence in patients with central nervous system signs and symptoms.
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Origins and clinical implications of aneuploidy in early bladder cancer.
Stanley E. Shackney,George Berg,Sheryl R. Simon,Jeffrey Cohen,Suresh Amina,William Pommersheim,Robert Yakulis,Scott Wang,Michelle Uhl,Charles A. Smith,Agnese A. Pollice,Robert J. Hartsock +11 more
TL;DR: It is concluded that DNA multiploidy and hypertetraploidy are markers of advanced stages of genetic evolution in human bladder cancer.
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Aneuploidy in Breast Cancer: A Fluorescence In Situ Hybridization Study
Stanley E. Shackney,Sarita G. Singh,Robert Yakulis,Charles A. Smith,Agnese A. Pollice,Susan Petruolo,Alan S. Waggoner,Robert J. Hartsock +7 more
TL;DR: The FISH data suggested that aneuploidy arises by a process of chromosome complement doubling with subsequent chromosome loss, and in tumors that exhibited evidence of more than one round of chromosomes complement doubling, the selective accumulation of multiple copies of specific chromosomes or chromosome segments was common.
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•Journal Article
Intracellular coexpression of epidermal growth factor receptor, Her-2/neu, and p21ras in human breast cancers: evidence for the existence of distinctive patterns of genetic evolution that are common to tumors from different patients
Stanley E. Shackney,Agnese A. Pollice,Charles Allen Smith,Laura E. Janocko,Lillian Sweeney,Kathryn A. Brown,Sarita G. Singh,Ling-Ping Gu,Robert Yakulis,Joseph F. Lucke +9 more
TL;DR: The two major genetic evolutionary pathways identified in this study are an aneuploid, Her-2/neu overexpression-driven pathway seen in 59 of 94 tumors, and a diploids, EGFR overexpression-driven pathways seen in 19 of 96 tumors.
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Assessing sequential oncogene amplification in human breast cancer
Laura E. Janocko,Joseph F. Lucke,David W. Groft,Kathryn A. Brown,Charles Allen Smith,Agnese A. Pollice,Sarita G. Singh,Robert Yakulis,Robert J. Hartsock,Stanley E. Shackney +9 more
TL;DR: The frequencies of amplification and patterns of co-amplification of c-myc, HER-2/neu, and H-ras were studied in a group of 84 breast cancers and a model in which JC-A amplification occurred early suggested that there is a preferred sequence of amplification of these oncogenes in breast cancer.
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