Robert Webster
Bayer HealthCare Pharmaceuticals
16 Papers
208 Citations
Robert Webster is an academic researcher from Bayer HealthCare Pharmaceuticals. The author has contributed to research in topics: Cationic polymerization & Enantioselective synthesis. The author has an hindex of 8, co-authored 16 publications. Previous affiliations of Robert Webster include University of Toronto.
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Papers
Reagent-controlled regiodivergent resolution of unsymmetrical oxabicyclic alkenes using a cationic rhodium catalyst.
TL;DR: The Rh(I) catalyzed regiodivergent addition of heteroatom nucleophiles to racemic oxabicyclic alkenes produces good yields of regioisomeric products each in high ee.
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Practical asymmetric synthesis of bioactive aminotetralins from a racemic precursor using a regiodivergent resolution.
TL;DR: Catalyst-controlled asymmetric ring opening of a racemic oxabicyclic alkene leads to two readily separable regioisomeric products both in excellent ee.
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Rh(I)-Catalyzed Ring-Opening of Hetaryne−Furan Diels−Alder Adducts: Rapid Access to Stereochemically Defined Heterocyclic Scaffolds
TL;DR: Probing the nucleophilic ring-opening of various bicyclic hetaryne-furan Diels-Alder adducts revealed that efficient reactivity could be observed with heteroatom nucleophiles by using a cationic Rh(I) complex in combination with a chiral Josiphos-type phosphine ligand.
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Rhodium-Catalyzed Asymmetric Cycloisomerization and Parallel Kinetic Resolution of Racemic Oxabicycles.
Charles C. J. Loh,Matthias Schmid,Robert Webster,Andy Yen,Shabnam K. Yazdi,Patrick T. Franke,Mark Lautens +6 more
TL;DR: This work reports the first rhodium-catalyzed asymmetric cycloisomerization of meso-oxabicyclic alkenes tethered to bridgehead nucleophiles, thus providing access to tricyclics scaffolds through a myriad of enantioselective C-O, C-N, and C-C bond formations.
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Conformational effects in diastereoselective aryne Diels-Alder reactions: synthesis of benzo-fused [2.2.1] heterobicycles.
Robert Webster,Mark Lautens +1 more
TL;DR: It was found that the diastereoselectivity of the Diels-Alder reaction between arynes and substituted furans is highly sensitive to substitution, which affects the reactive conformation, so this methodology offers rapid and convenient access to enantiomerically pure bicyclic scaffolds which are difficult to prepare by other means.
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