Robert W. Putnam
Wright State University
125 Papers
768 Citations
Robert W. Putnam is an academic researcher from Wright State University. The author has contributed to research in topics: Intracellular pH & Locus coeruleus. The author has an hindex of 34, co-authored 125 publications.
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Papers
Cellular mechanisms involved in CO2 and acid signaling in chemosensitive neurons
TL;DR: A multiple factors model is proposed for central chemosensitive neurons in which multiple signals that affect multiple ion channel targets result in the final neuronal response to changes in CO(2)/H(+).
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Development of in vivo ventilatory and single chemosensitive neuron responses to hypercapnia in rats.
TL;DR: The data suggest that CO2 sensitivity of ventilation in rats may exist in two forms, a high-sensitivity neonatal (or fetal) form and a lower-s sensitivity adult form, with a critical window of very low sensitivity during the period of transition between the two (approximately P8).
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Intracellular pH response to hypercapnia in neurons from chemosensitive areas of the medulla
TL;DR: The data indicate that pHi regulation differs between neurons in chemosensitive (NTS and VLM) and nonchemosensitive areas of the medulla, pHi recovery is due solely to Na+/H+ exchange in all four areas, and Na+ or H+ exchange is more sensitive to inhibition by extracellular acidosis in NTS and V LM neurons than in IO and Hyp neurons.
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Neonatal maturation of the hypercapnic ventilatory response and central neural CO2 chemosensitivity
TL;DR: Central neural mechanisms, including altered CO2 sensitivity of neurons among the various sites of central CO2 chemosensitivity, changes in astrocytic function during development, and the relative maturation of synaptic processes may also determine how plastic the response to CO2 is at any particular age are discussed.
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Intracellular pH Regulation
Robert W. Putnam
- 01 Jan 2001
TL;DR: This chapter discusses the pH level in the cytoplasm and various compartments of a cell, the variety of mechanisms available to a cell to regulate its pH i and the functional consequences of changes in pH i.
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