Robert W. Byrnes
University of Wisconsin–Milwaukee
27 Papers
336 Citations
Robert W. Byrnes is an academic researcher from University of Wisconsin–Milwaukee. The author has contributed to research in topics: DNA damage & Chemistry. The author has an hindex of 15, co-authored 27 publications. Previous affiliations of Robert W. Byrnes include San Diego Supercomputer Center & Roswell Park Cancer Institute.
Chat about Author
Papers
Direct reaction of H2O2 with sulfhydryl groups in HL-60 cells: zinc-metallothionein and other sites.
TL;DR: Partial purification of cell cytosol using Sephadex G-75 chromatography showed that zinc-metallothionein (Zn-MT) was induced by 24-h treatment with 100 microM ZnCl2, but the cellular glutATHione content and glutathione peroxidase and catalase activities were unaffected.
147
•Journal Article
Intracellular DNA strand scission and growth inhibition of Ehrlich ascites tumor cells by bleomycins.
TL;DR: The generation of this class of damaged DNA correlates more closely with concentration-dependent growth inhibition by each of the six forms of bleomycin than the degree of random strand scission.
66
Oxidation-reduction reactions in Ehrlich cells treated with copper-neocuproine
TL;DR: To explain the (NC)2Cu-dependent generation of hydroxyl radical, it is hypothesized that glutathione successfully competes for Cu(I), converting it to a redox-active form that can catalyze the reduction of molecular oxygen to .OH.
32
The encyclopedia of life project: grid software and deployment
Wilfred W. Li,Robert W. Byrnes,Jim Hayes,Adam Birnbaum,Vicente M. Reyes,Atif Shahab,C Mosley,Dmitry Pekurovsky,Gregory B. Quinn,Ilya N. Shindyalov,Henri Casanova,Larry Ang,Francine Berman,Peter Arzberger,Mark A. Miller,Philip E. Bourne +15 more
TL;DR: Some common problems and expectations of grid computing for high throughput proteomics are discussed and a domain-specific bioinformatics workflow management system is built on top of APST, which further streamlines grid deployment of life science applications.
29
Iron requirement for cellular DNA damage and growth inhibition by hydrogen peroxide and bleomycin
TL;DR: Growth inhibition and both single- and double-strand DNA damage caused by bleomycin were substantially reduced or eliminated in iron-deficient cells, while major pools of cellular iron were reduced in both cell types.
27