Robert Ulrey
Children's National Medical Center
9 Papers
19 Citations
Robert Ulrey is an academic researcher from Children's National Medical Center. The author has contributed to research in topics: Medicine & Antigen. The author has an hindex of 4, co-authored 9 publications. Previous affiliations of Robert Ulrey include George Mason University.
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Papers
SARS-CoV-2–specific T cells are rapidly expanded for therapeutic use and target conserved regions of the membrane protein
Michael D. Keller,Katherine M. Harris,Mariah Jensen-Wachspress,Vaishnavi V. Kankate,Haili Lang,Christopher A. Lazarski,Jessica Durkee-Shock,Ping-Hsien Lee,Kajal Chaudhry,Kathleen Webber,Anushree Datar,Madeline Terpilowski,Emily K. Reynolds,Eva M. Stevenson,Stéphanie Val,Zoe Shancer,Nan Zhang,Robert Ulrey,Uduak Ekanem,Maja Stanojevic,Ashley Geiger,Hua Liang,Fahmida Hoq,Allistair Abraham,Patrick J. Hanley,C. Russell Cruz,Kathleen Ferrer,Lesia K. Dropulic,Krista Gangler,Peter D. Burbelo,R. Brad Jones,Jeffrey I. Cohen,Catherine M. Bollard +32 more
TL;DR: This study shows that SARS-CoV-2 directed T-cell immunotherapy targeting structural proteins, most importantly membrane protein, should be feasible for the prevention or early treatment of Sars-Cov-2 infection in immunocompromised patients with blood disorders or after bone marrow transplantation to achieve antiviral control while mitigating uncontrolled inflammation.
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Immunotherapy of Relapsed and Refractory Solid Tumors With Ex Vivo Expanded Multi-Tumor Associated Antigen Specific Cytotoxic T Lymphocytes: A Phase I Study
Amy B. Hont,C. Russell Cruz,Robert Ulrey,Barbara O’Brien,Maja Stanojevic,Anushree Datar,Shuroug Albihani,Devin Saunders,Ryo Hanajiri,Karuna Panchapakesan,Sam Darko,Payal Banerjee,Maria Fernanda Fortiz,Fahmida Hoq,Haili Lang,Yunfei Wang,Patrick J. Hanley,Jeffrey S. Dome,Catherine M. Bollard,Holly J. Meany +19 more
TL;DR: TAA-Ts safely induced disease stabilization, prolonged time to progression, and were associated with antigen spreading and a reduction in circulating tumor-associated antigen DNA levels in patients with relapsed/refractory solid tumors without lymphodepleting chemotherapy before infusion.
Impact of Mesenchymal Stromal Cell Delivery through Cardiopulmonary Bypass on Postnatal Neurogenesis
Takuya Maeda,Kamil Sarkislali,Camille Leonetti,Nisha Kapani,Zaenab Dhari,Ibtisam Al Haj,Robert Ulrey,Patrick J. Hanley,Richard A. Jonas,Richard A. Jonas,Nobuyuki Ishibashi,Nobuyuki Ishibashi +11 more
TL;DR: MSC delivery through CPB has the potential to mitigate effects of CPB on neural stem/progenitor cells and promote migration of neuroblasts and these findings suggest that MSC treatment changes neuroblast distribution within the subventricular zone.
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Critical testing and parameters for consideration when manufacturing and evaluating tumor-associated antigen-specific T cells.
TL;DR: The unique tests associated with ex vivo-expanded tumor-associated antigen T cells (TAA-T) include functional assays to determine potency, specificity, and identity, tests for pathogenic contaminants, such as bacteria and fungus as well as other contaminants such as Mycoplasma and endotoxin, and recommendations for critical quality attributes and parameters associated with the expansion of TAA-Ts.
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Identification of novel HLA-restricted preferentially expressed antigen in melanoma peptides to facilitate off-the-shelf tumor-associated antigen-specific T-cell therapies.
Maja Stanojevic,Amy B. Hont,Ashley Geiger,Samuel O'Brien,Robert Ulrey,Melanie Grant,Anushree Datar,Ping-Hsien Lee,Haili Lang,Conrad Russell Y. Cruz,Patrick J. Hanley,A. John Barrett,Michael D. Keller,Catherine M. Bollard +13 more
TL;DR: In this paper, the authors used peptide libraries of 125 overlapping 15-mer peptides spanning the entire melanoma protein sequence to identify HLA class I- and II-restricted epitopes.
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