Robert T. Tranquillo
University of Pennsylvania
8 Papers
48 Citations
Robert T. Tranquillo is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Random walk & Cell migration. The author has an hindex of 6, co-authored 8 publications.
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Papers
Measurement of the chemotaxis coefficient for human neutrophils in the under-agarose migration assay.
TL;DR: This paper demonstrates the measurement of cell migration parameters that do, in fact, characterize the intrinsic cell chemosensory movement responses using cell density profiles obtained in the linear under-agarose assay, and proposes a priori the dependence of chi on attractant concentration.
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Gradient perception by neutrophil leucocytes, continued.
TL;DR: The mechanism by which neutrophil leucocytes exhibit chemotaxis continues to be the subject of debate and some information is given to give attention to some information that should help clarify some of the points raised by these articles.
25
Consequences of chemosensory phenomena for leukocyte chemotactic orientation.
Robert T. Tranquillo,Douglas A. Lauffenburger +1 more
- 01 Feb 1986
TL;DR: The probabilistic cell orientation model of Lauffenburger is extended here to assess the consequences of recently discovered receptor phenomena: “down-regulation” of total surface receptor number, spatial asymmetry of surface receptors, and existence of a higher-affinity receptor subpopulation.
17
A stochastic model for chemosensory cell movement: application to neutrophil and macrophage persistence and orientation
TL;DR: A stochastic mathematical model for cell locomotion based on kinetic fluctuations in chemoattractant receptor binding is reported on, which proves to be capable of stimulating cell paths similar to those observed experimentally for two cell types examined to date.
10
A stochastic model for chemosensory cell movement: application to neutrophil and macrophage persistence and orientation
TL;DR: The concept of signal “noise” can quantitatively unify the major characteristics of leukocyte random motility and chemotaxis and suggest that chemosensory cell movement behavior may be based on a “usefully” imperfect integrated signal response system, which allows both random and directed searches under appropriate conditions.
3