Robert Perrill
University of Arizona
6 Papers
57 Citations
Robert Perrill is an academic researcher from University of Arizona. The author has contributed to research in topics: Coccidioides & Coccidioides posadasii. The author has an hindex of 6, co-authored 6 publications. Previous affiliations of Robert Perrill include Center for Excellence in Education & Veterans Health Administration.
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Papers
Detection and phylogenetic analysis of Coccidioides posadasii in Arizona soil samples
TL;DR: Assessment of applicability of PCR, with its potential for high-throughput screening, as a method for identifying Coccidioides-containing soils found to contain the pathogen in the Tucson area.
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Improved protection of mice against lethal respiratory infection with Coccidioides posadasii using two recombinant antigens expressed as a single protein.
Lisa F. Shubitz,Lisa F. Shubitz,Jieh Juen Yu,Chiung Yu Hung,Theo N. Kirkland,Tao Peng,Tao Peng,Robert Perrill,Robert Perrill,Julie Simons,Julie Simons,Jianmin Xue,Roger A. Herr,Garry T. Cole,John N. Galgiani,John N. Galgiani +15 more
TL;DR: Two recombinant antigens which individually protect mice from lethal intranasal infection were studied in combination, either as a mixture of two separately expressed proteins or as a single chimeric expression product.
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Protection of mice against Coccidioides immitis intranasal infection by vaccination with recombinant antigen 2/PRA.
Lisa F. Shubitz,Lisa F. Shubitz,Tao Peng,Tao Peng,Tao Peng,Robert Perrill,Robert Perrill,Julie Simons,Julie Simons,Kris I. Orsborn,Kris I. Orsborn,Kris I. Orsborn,John N. Galgiani +12 more
TL;DR: These studies support rAg2/PRA vaccination to prevent coccidioidomycosis.
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Modeling Nikkomycin Z Dosing and Pharmacology in Murine Pulmonary Coccidioidomycosis Preparatory to Phase 2 Clinical Trials
Lisa F. Shubitz,Hien T. Trinh,Robert Perrill,C. Michael Thompson,Nathan J. Hanan,John N. Galgiani,David E. Nix +6 more
TL;DR: Comparative data show that plasma levels of NikZ that nearly eradicate Coccidioides in mice are achievable in patients and provide a plausibly effective dose range for initial phase 2 clinical studies.
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Vaccine-Induced Cellular Immune Responses Differ from Innate Responses in Susceptible and Resistant Strains of Mice Infected with Coccidioides posadasii
Lisa F. Shubitz,Sharon M. Dial,Robert Perrill,Rachael Casement,John N. Galgiani,John N. Galgiani +5 more
TL;DR: Investigation of strains of mice with various susceptibilities revealed that C57BL/6 mice were highly susceptible to the disease following intranasal infection, DBA/2n mice were intermediate, and Swiss-Webster mice were innately resistant.
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