Robert N. Fontaine
University of Cincinnati Academic Health Center
6 Papers
170 Citations
Robert N. Fontaine is an academic researcher from University of Cincinnati Academic Health Center. The author has contributed to research in topics: Serine & Risk factor. The author has an hindex of 6, co-authored 6 publications.
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Papers
Genetic and environmental risk factors for intracerebral hemorrhage: preliminary results of a population-based study.
Daniel Woo,Laura Sauerbeck,Brett M. Kissela,Jane Khoury,Jerzy P. Szaflarski,James Gebel,Rakesh Shukla,Arthur M. Pancioli,Edward C. Jauch,Anil G. Menon,Ranjan Deka,Janice Carrozzella,Charles J Moomaw,Robert N. Fontaine,Joseph P. Broderick +14 more
TL;DR: In this paper, the authors report a preplanned, midpoint analysis of the first population-based, case-control study that examines both genetic and environmental risk factors of ICH.
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Molecular cloning and expression of cDNA for rat pancreatic cholesterol esterase.
TL;DR: Analysis of the cholesterol esterase structure revealed a repetitive sequence enriched with Pro, Asp, Glu, Ser, and Thr residues at the C-terminal end of the protein, which is reminiscent of the PEST-rich sequences in short-lived proteins, suggesting that cholesterol Esterase may have a short half-life in vivo.
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Identification of the active site serine in pancreatic cholesterol esterase by chemical modification and site-specific mutagenesis.
TL;DR: These studies definitively identified serine 194 in the catalytic site of pancreatic cholesterol esterase.
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Site-specific mutagenesis of an essential histidine residue in pancreatic cholesterol esterase.
TL;DR: The histidine residue essential for the catalytic activity of pancreatic cholesterol esterase (carboxylester lipase) has been identified in this study using sequence comparison and site-specific mutagenesis techniques.
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Structure of the rat pancreatic cholesterol esterase gene.
TL;DR: The organization of the cholesterol ester enzyme gene suggests its divergent evolution with other members of the serine esterase gene family.
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