Robert Morbitzer
University of Tübingen
21 Papers
1 Citations
Robert Morbitzer is an academic researcher from University of Tübingen. The author has contributed to research in topics: TAL effector & Gene. The author has an hindex of 14, co-authored 16 publications. Previous affiliations of Robert Morbitzer include University of California, Davis & Center for Integrated Protein Science Munich.
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Papers
A novel TALE nuclease scaffold enables high genome editing activity in combination with low toxicity
Claudio Mussolino,Robert Morbitzer,Fabienne Lütge,Nadine Dannemann,Thomas Lahaye,Toni Cathomen +5 more
TL;DR: The combination of high nuclease activity with reduced cytotoxicity and the simple design process marks TALENs as a key technology platform for targeted modifications of complex genomes.
Regulation of selected genome loci using de novo-engineered transcription activator-like effector (TALE)-type transcription factors
TL;DR: The data demonstrate that the TALE scaffold can be tailored to target user-defined DNA sequences in whole genomes and mediates specific interaction with G nucleotides that thus far could not be targeted specifically by any known RVD type.
393
Xanthomonas axonopodis virulence is promoted by a transcription activator-like effector-mediated induction of a SWEET sugar transporter in cassava.
Megan Cohn,Rebecca Bart,Mikel Shybut,Douglas Dahlbeck,Michael A. Gomez,Robert Morbitzer,Bi-Huei Hou,Wolf B. Frommer,Thomas Lahaye,Brian J. Staskawicz +9 more
TL;DR: Combined systematic analysis of the TAL effector complement of Xanthomonas axonopodis pv.
246
TALENs facilitate targeted genome editing in human cells with high specificity and low cytotoxicity
Claudio Mussolino,Jamal Alzubi,Eli J. Fine,Robert Morbitzer,Thomas J. Cradick,Thomas Lahaye,Gang Bao,Toni Cathomen +7 more
TL;DR: The results link nuclease-associated toxicity to off-target cleavage activity and corroborate TALENs as a highly specific platform for future clinical translation.
A Modular Plasmid Assembly Kit for Multigene Expression, Gene Silencing and Silencing Rescue in Plants
Andreas Binder,Jayne Lambert,Robert Morbitzer,Claudia Popp,Thomas Ott,Thomas Lahaye,Martin Parniske +6 more
TL;DR: A GG based toolkit for the flexible construction of binary plasmids for transgene expression in plants and assembled an RNA interference module for the construction of intron-spliced hairpin RNA constructs, and demonstrated silencing of GFP in N. benthamiana.