Robert McMaster
University of British Columbia
36 Papers
187 Citations
Robert McMaster is an academic researcher from University of British Columbia. The author has contributed to research in topics: Leishmania major & Transplantation. The author has an hindex of 14, co-authored 36 publications. Previous affiliations of Robert McMaster include Vancouver Coastal Health.
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Papers
Leishmania GP63 alters host signaling through cleavage-activated protein tyrosine phosphatases.
Maria Adelaida Gomez,Irazú Contreras,Irazú Contreras,Maxime Hallé,Michel L. Tremblay,Robert McMaster,Martin Olivier,Martin Olivier +7 more
TL;DR: The data present a mechanism of cleavage-dependent activation of macrophage PTPs by an obligate intracellular pathogen and show that internalization of GP63, a key Leishmania virulence factor, into host macrophages is a strategy the parasite uses to interact and survive within its host.
208
Leishmania donovani promastigotes evade the antimicrobial activity of neutrophil extracellular traps.
TL;DR: It is suggested that neutrophil extracellular traps may contribute to the containment of L. donovani promastigotes at the site of inoculation, thereby facilitating their uptake by mononuclear phagocytes.
Leishmania Repression of Host Translation through mTOR Cleavage Is Required for Parasite Survival and Infection
Maritza Jaramillo,Maria Adelaida Gomez,Ola Larsson,Marina Tiemi Shio,Ivan Topisirovic,Irazú Contreras,Randi Luxenburg,Amy B. Rosenfeld,Rodney Colina,Robert McMaster,Martin Olivier,Mauro Costa-Mattioli,Nahum Sonenberg +12 more
TL;DR: It is shown that the Leishmania protease GP63 cleaves the mammalian/mechanistic target of rapamycin (mTOR), a serine/threonine kinase that regulates the translational repressor 4E-BP1, which serves as major targets for host translational control.
183
Exosomal miR-142-3p is increased during cardiac allograft rejection and augments vascular permeability through down-regulation of endothelial RAB11FIP2 expression
Ihdina Sukma Dewi,Selvi Celik,Anna Karlsson,Zsuzsanna Hollander,Karen K. Lam,Janet Wilson McManus,Scott J. Tebbutt,Raymond T. Ng,Paul Keown,Robert McMaster,Bruce M. McManus,Jenny Öhman,Olof Gidlöf +12 more
TL;DR: A novel mechanism whereby miR-142-3p, a microRNA enriched in exosomes during acute cellular rejection, is transferred to endothelial cells and compromises endothelial barrier function via down-regulation of RAB11FIP2 is identified.
Leishmania major: Production of recombinant gp63, its antigenicity and immunogenicity in mice
TL;DR: The gp63 fusion protein did not protect mice of either healer or nonhealer phenotype from challenge infection with live promatigotes, suggesting the presence of native determinants in the recombinant protein.
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