Robert M. Lowe
University of Washington
4 Papers
40 Citations
Robert M. Lowe is an academic researcher from University of Washington. The author has contributed to research in topics: Type 1 diabetes & Single-strand conformation polymorphism. The author has an hindex of 4, co-authored 4 publications.
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Papers
HLA associations in type 1 diabetes among patients not carrying high-risk DR3-DQ2 or DR4-DQ8 haplotypes.
Dag E. Undlien,Ingrid Kockum,Kjersti S. Rønningen,Robert M. Lowe,C. B. Saanjeevi,Jinko Graham,B. A. Lie,Hanne E. Akselsen,Åke Lernmark,Erik Thorsby +9 more
TL;DR: The study clearly demonstrates that HLA associations in type 1 diabetes extends far beyond the well-known associations with the DR4-D Q8 and DR3-DQ2 haplotypes, and suggests that there is a hierarchy of HLA class II haplotypes conferring risk to develop type 1abetes.
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The length of the CTLA-4 microsatellite (AT)N-repeat affects the risk for type 1 diabetes. Diabetes Incidence in Sweden Study Group.
Robert M. Lowe,Jinko Graham,Greg C. Sund,Ingrid Kockum,Mona Landin-Olsson,Jonathan B. Schaefer,Carina Törn,Åke Lernmark,Gisela Dahlquist +8 more
TL;DR: In this article, the 3'-end (AT)n repeat region of the CTLA-4 gene represents a recessive risk factor for type 1 diabetes, and the long alleles, partitioned into intermediate (I) length and very long (VL) alleles were found to act recessively in conferring diabetes risk.
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The beta cell glucokinase promoter variant is an unlikely risk factor for diabetes mellitus
Kourosh Lotfi,Greg C. Sund,Robert M. Lowe,Jinko Graham,Mona Landin-Olsson,Ingrid Kockum,Samir S. Deeb,Åke Lernmark +7 more
TL;DR: The results suggest that the –30 beta-cell glucokinase promoter variant is not associated with IDDM, and is therefore an attractive candidate gene for both insulin dependent (IDDM) and non-insulin-dependent (NIDs) diabetes mellitus.
Genetic Effects on Age-Dependent Onset and Islet Cell Autoantibody Markers in Type 1 Diabetes
Jinko Graham,William Hagopian,Ingrid Kockum,Lou Sheng Li,CB Sanjeevi,Robert M. Lowe,Jonathan B. Schaefer,M Zarghami,Heather L. Day,Mona Landin-Olsson,Jerry P. Palmer,Marta Janer-Villanueva,Leroy Hood,Göran Sundkvist,Åke Lernmark,Norman E. Breslow,Gisela Dahlquist,G Blohmé +17 more
TL;DR: It is concluded that age and genetic factors such as HLA-DQ and INS VNTR need to be combined with islet autoantibody markers when evaluating the risk for type 1 diabetes development.