D2-like receptors in the kidney have been suggested to be important in the regulation of renin release but the D2-like subtype(s) expressed in juxtaglomerular (JG) cells is not known. Therefore, we determined which of the D2-like family of dopamine receptors is located in primary cultures of rat juxtaglomerular (JG) cells.

Dopamine D3 receptors in rat juxtaglomerular cells.

Dopamine, an intrarenal regulator of sodium transport, is important in the pathogenesis of hypertension. The transduction of D1-like receptors in renal proximal tubules is defective in animal models of genetic hypertension. The defect is associated with an impaired regulation of proximal tubular sodium transport and cosegregates with hypertension in rats. Moreover, mice lacking one or both D1A receptor alleles develop hypertension. Extrasynaptic D3 receptors in renal tubules and juxtaglomerular cells may also regulate renal sodium transport and renin secretion while presynaptic D3 receptors may act as autoreceptors to inhibit neural norepinephrine release. Mice lacking one or both D3 alleles have elevated systolic blood pressure and developed diastolic hypertension. Although basal urine flow, sodium excretion, and glomerular filtration rate are similar, mice homozygous to the D3 receptor have an impaired ability to excrete an acute saline load compared to heterozygous and wild type mice. These studies suggest that abnormalities in dopamine receptor genes or their regulation may lead to the development of hypertension via different pathogenetic mechanisms.

Transgenic Mice to Study the Role of Dopamine Receptors in Cardiovascular Function

DOPAMINE RECEPTOR (DAR) SUBTYPE EXPRESSION AND FUNCTION IN RAT JUXTAGLOMERULAR (JG) CELLS. † 2216A

Dopamine receptor (dar) subtype expression and function in rat juxtaglomerular (jg) cells. † 2216a

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Dopamine receptor (dar) subtype expression and function in rat juxtaglomerular (jg) cells. † 2216a