Robert J. Levy
University of Illinois at Chicago
23 Papers
483 Citations
Robert J. Levy is an academic researcher from University of Illinois at Chicago. The author has contributed to research in topics: Calcification & Aortic valve. The author has an hindex of 15, co-authored 23 publications. Previous affiliations of Robert J. Levy include Harvard University & Brigham and Women's Hospital.
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Papers
Bioprosthetic heart valve failure: pathology and pathogenesis.
TL;DR: Research into degenerative processes leading to late primary valve failure, including calcification, has suggested potential approaches for inhibiting calcification and other degradative phenomena.
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Mechanism of calcification of porcine bioprosthetic aortic valve cusps: Role of T-lymphocytes
Robert J. Levy,Robert J. Levy,Robert J. Levy,Frederick J. Schoen,Frederick J. Schoen,Frederick J. Schoen,Susan L. Howard,Susan L. Howard,Susan L. Howard +8 more
TL;DR: Calcification of glutaraldehyde-preserved porcine aortic valve bioprosthetic cusps limits their success as cardiac valve substitutes, and normal T-lymphocyte function is not necessary and immunologic processes do not contribute to this process.
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Biological Sealants and Knitted Dacron: Porosity and Histological Comparisons of Vascular Graft Materials with and without Collagen and Fibrin Glue Pretreatments
TL;DR: The collagen-impregnated and fibrin glue-treated grafts differed in the intensity of the inflammatory response and tissue adhesion, possibly related to the degree of collagen cross-linking, which may have important implications regarding structure of the pseudointima in vascular grafts sealed with these materials.
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Antimineralization treatments for bioprosthetic heart valves. Assessment of efficacy and safety.
TL;DR: The preclinical investigation of efficacy and safety of antimineralization treatments comprises four essential steps: subcutaneous implantation in small animals, in vitro biomechanical studies of hemodynamics and durability, morphology of unimplanted valves, and circulatory implants in large animals.
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Controlled release of diphosphonate to inhibit bioprosthetic heart valve calcification: dose-response and mechanistic studies
Gershon Golomb,Gershon Golomb,Gershon Golomb,Robert Langer,Robert Langer,Frederick J. Schoen,Mary Sue Smith,Yong Mi Choi,Robert J. Levy,Robert J. Levy +9 more
TL;DR: It is concluded that both in vitro and in vivo release of EHDP from the 20% w/w EH DP matrices was suitable to inhibit BHV calcification and that this effect is most likely due to interaction of EhDP with the BhV tissue surface.
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