Robert J Autry
St. Jude Children's Research Hospital
19 Papers
2 Citations
Robert J Autry is an academic researcher from St. Jude Children's Research Hospital. The author has contributed to research in topics: Biology & Medicine. The author has an hindex of 4, co-authored 8 publications. Previous affiliations of Robert J Autry include University of Tennessee Health Science Center.
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Papers
Integrative genomic analyses reveal mechanisms of glucocorticoid resistance in acute lymphoblastic leukemia
Robert J Autry,Robert J Autry,Steven W. Paugh,Robert Carter,Lei Shi,Jingjing Liu,Daniel C. Ferguson,Calvin E. Lau,Erik J. Bonten,Wenjian Yang,J. Robert McCorkle,Jordan A. Beard,John C. Panetta,Jonathan D. Diedrich,Kristine R. Crews,Deqing Pei,Christopher J. Coke,Sivaraman Natarajan,Alireza Khatamian,Seth E. Karol,Elixabet Lopez-Lopez,Barthelemy Diouf,Colton Smith,Yoshihiro Gocho,Kohei Hagiwara,Kathryn G. Roberts,Stanley Pounds,Steven M. Kornblau,Wendy Stock,Elisabeth Paietta,Mark R. Litzow,Hiroto Inaba,Charles G. Mullighan,Sima Jeha,Ching-Hon Pui,Cheng Cheng,Daniel Savic,Jiyang Yu,Charles Gawad,Mary V. Relling,Mary V. Relling,Jun J. Yang,William E. Evans,William E. Evans +43 more
TL;DR: Manipulation of CELSR2 recapitulated glucocorticoid resistance in human leukemia cell lines and revealed a synergistic drug combination (prednisolone and venetoclax) that mitigated resistance in mouse xenograft models.
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Comprehensive analysis of mutational signatures reveals distinct patterns and molecular processes across 27 pediatric cancers
Venu Thatikonda,S M Ashiqul Islam,Robert J Autry,Barbara C. Jones,Susanne Gröbner,Gregor Warsow,Barbara Hutter,D. Huebschmann,Stefan Fröhling,Marcel Kool,Mirjam Blattner-Johnson,David T. Jones,Ludmil B. Alexandrov,Stefan M. Pfister,Natalie Jäger +14 more
TL;DR: In this paper , the authors analyzed single base substitutions and small insertions and deletions in pediatric cancers encompassing 785 whole-genome sequenced tumors from 27 molecularly defined cancer subtypes.
Genetics of ancestry-specific risk for relapse in acute lymphoblastic leukemia
Seth E. Karol,Eric C. Larsen,C. Cheng,Xueyuan Cao,Wenjian Yang,Laura B. Ramsey,Christian A. Fernandez,Joseph R. McCorkle,Steven W. Paugh,Robert J Autry,Elixabet Lopez-Lopez,Barthelemy Diouf,Sima Jeha,C H Pui,Elizabeth A. Raetz,Naomi J. Winick,William L. Carroll,Stephen P. Hunger,Mignon L. Loh,Meenakshi Devidas,William E. Evans,Jun J. Yang,M. V. Relling +22 more
TL;DR: The contribution of germline genetic factors to relapse in 2225 children treated on Children’s Oncology Group trial AALL0232 was evaluated and 302 germline single-nucleotide polymorphisms (SNPs) associated with relapse after adjusting for treatment and ancestry and 715 additional SNPsassociated with relapse in an ancestry-specific manner were identified.
Pharmacogenomics of intracellular methotrexate polyglutamates in patients’ leukemia cells in vivo
Elixabet Lopez-Lopez,Robert J Autry,Robert J Autry,Colton Smith,Wenjian Yang,Steven W. Paugh,John C. Panetta,Kristine R. Crews,Erik J. Bonten,Brandon Smart,Deqing Pei,J. Robert McCorkle,Barthelemy Diouf,Kathryn G. Roberts,Lei Shi,Stanley Pounds,Cheng Cheng,Charles G. Mullighan,Ching-Hon Pui,Mary V. Relling,Mary V. Relling,William E. Evans,William E. Evans +22 more
TL;DR: These findings provide insights into mechanisms underlying interpatient differences in intracellular accumulation of MTXPG in leukemia cells and its antileukemic effects.
Genome-wide CRISPR screen reveals PSMA6 to be an essential gene in pancreatic cancer cells.
Jesse Bakke,Jesse Bakke,William C. Wright,William C. Wright,Anthony E. Zamora,Peter Oladimeji,Jeremy Chase Crawford,Christopher Trent Brewer,Christopher Trent Brewer,Robert J Autry,Robert J Autry,William E. Evans,Paul G. Thomas,Taosheng Chen,Taosheng Chen +14 more
TL;DR: Spheroid formation assays and flow cytometry analysis showed that PSMA6 is critical for survival in many pancreatic ductal carcinoma cell models, and bortezomib, a proteasome inhibitor, was especially toxic in PANC-1 cells.