A coated implantable medical device 10 includes a structure 12 adapted for introduction into the vascular system, esophagus, trachea, colon, biliary tract, or urinary tract; at least one layer 18 of a bioactive material positioned over the structure 12; and at least one porous layer 20 positioned over the bioactive material layer 18. Preferably, the structure 12 is a coronary stent, and the bioactive material is at least one of heparin, dexamethasone or a dexamethasone derivative. The device 10 includes layers 18 and 22 of heparin and dexamethasone, the layer 22 of dexamethasone being positioned above the layer 18 of heparin. The layers of bioactive material also can be individual materials or a combination of different materials. Unexpectedly, the more soluble heparin markedly promotes the release of the less soluble dexamethasone above it. The porous layer 20 is composed of a polymer applied by vapor or plasma deposition and provides a controlled release of the bioactive material. It is particularly preferred that the polymer is a polyimide, parylene or a parylene derivative, which is deposited without solvents, heat or catalysts, merely by condensation of a monomer vapor.

Coated implantable medical device

A drug eluting medical device is disclosed. The device includes a barrier layer for reducing the rate of release of a drug.

Barriers for polymer-coated implantable medical devices and methods for making the same

A membrane that reduces the rate at which a therapeutic substance is released from an implantable medical device, such as a stent, is disclosed.

Rate-reducing membrane for release of an agent

A therapeutic agent delivery device that can allows is particularly suitable for delivery of a therapeutic agent to limited access regions, such as the posterior chamber of the eye and inner ear. Preferred devices of the invention are minimally invasive, refillable and may be easily fixed to the treatment area. Preferred delivery devices of the invention also include those that comprise a non-linear shaped body member housing one or more substances and a delivery mechanism for the sustained delivery of the one or more substances from the non-linear shaped body member to the patient.

Devices for intraocular drug delivery

Stent mounting assembly and a method of using the same to coat a stent

A coating composition, and method of applying such a composition under conditions of controlled humidity, for use in coating device surfaces to control and/or improve their ability to release bioactive agents in aqueous systems. The coating composition is particularly adapted for use with medical devices that undergo significant flexion and/or expansion in the course of their delivery and/or use, such as stents and catheters. The composition includes the bioactive agent in combination with a combination of a first polymer component such as polyalyl(meth)acrylate, polyaryl(meth)acrylate, polyaralkyl(meth)acrylate, or polyaryloxyalkyl(meth)acrylate and a second polymer component such as poly(ethylene-co-vinyl acetate).

Method and system for providing bioactive agent release coating

The invention provides implantable intraluminal medical devices that are fabricated of biodegradable materials. The invention further provides methods of treatment utilizing the devices.

Biodegradable implantable medical devices, methods and systems

The invention provides devices for treatment of a patient, wherein at least a portion of the device is provided with a biodegradable coating composed of multiple coated layers of biodegradable material. The invention further provides methods of treatment utilizing the devices.

Biodegradable coating compositions including multiple layers

The invention provides devices for treatment of a patient, wherein at least a portion of the device is provided with a biodegradable coating composed of a blend of bioactive agent and at least two biodegradable polymers or copolymers. The invention further provides methods of treatment utilizing the devices.

Biodegradable coating compositions comprising blends

La presente invention a trait a des dispositifs pour le traitement d'un patient, une portion du dispositif etant dote d'un revetement biodegradable constitue de plusieurs couches revetues de materiau biodegradable. L'invention a egalement trait a des procedes de traitement mettant en oeuvre les dispositifs.

Compositions de revetement biodegradables comprenant plusieurs couches

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