Robert Helton
Salk Institute for Biological Studies
5 Papers
Robert Helton is an academic researcher from Salk Institute for Biological Studies. The author has contributed to research in topics: Panic disorder & Anxiety. The author has an hindex of 4, co-authored 4 publications.
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Papers
Glyoxalase 1 and glutathione reductase 1 regulate anxiety in mice
Iiris Hovatta,Richard S. Tennant,Robert Helton,Robert A. Marr,Oded Singer,Jeffrey M. Redwine,Julie A. Ellison,Eric E. Schadt,Inder M. Verma,David J. Lockhart,Carrolee Barlow +10 more
TL;DR: Using a combination of behavioural analysis of six inbred mouse strains with quantitative gene expression profiling of several brain regions, the identification of 17 genes with expression patterns that correlate with anxiety-like behavioural phenotypes are identified.
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Mechanisms of aging in senescence-accelerated mice
Todd A. Carter,Jennifer A. Greenhall,Shigeo Yoshida,Sebastian Fuchs,Robert Helton,Anand Swaroop,David J. Lockhart,Carrolee Barlow +7 more
TL;DR: It is shown that combining the study of inbred mouse strains with interesting traits and gene-expression profiling can lead to the discovery of genes important for complex phenotypes, including a mutation in a fibroblast growth factor gene, Fgf1, and a mutations in and ectopic expression of the gene for the chemokine CCL19, which is involved in the inflammatory response.
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Usability and performance of the MicroGEM Sal6830, an RT-PCR saliva-based point-of-care platform to detect SARS-CoV-2 in primary healthcare settings with non-laboratory trained operators.
Val Mills,T. Owen Tyson,Robert Helton,Paula Hill-Collins,Sydney C. Hubbard,J. Anthony G. Scott,Jeffrey A. Hickey,Brian E. Root,Rachael O’Brien,Jillian Conte,Jo-Ann L. Stanton,J. Chapman +11 more
TL;DR: The Sal6830 platform is a fully self-contained, RT-PCR point-of-care device for detecting SARS-CoV-2 from saliva that takes less than thirty minutes to complete as discussed by the authors .
•Journal Article
Glyoxalase 1 and glutathione reductase 1 regulate anxiety in mice
Iiris Hovatta,Richard S. Tennant,Robert Helton,Robert A. Marr,Oded Singer,Jeffrey M. Redwine,Julie A. Ellison,Eric E. Schadt,Inder M. Verma,David J. Lockhart,Carrolee Barlow +10 more
TL;DR: In this article, a combination of behavioural analysis of six inbred mouse strains with quantitative gene expression profiling of several brain regions was used to identify 17 genes with expression patterns that correlate with anxiety-like behavioural phenotypes.
Failed Clearance of Aneuploid Embryonic Neural Progenitor Cells Leads to Excess Aneuploidy in the Atm-Deficient But Not the Trp53-Deficient Adult Cerebral Cortex
Michael J. McConnell,Dhruv Kaushal,Amy H. Yang,Marcy A. Kingsbury,Stevens K. Rehen,Kai Treuner,Robert Helton,Emily G. Annas,Jerold Chun,Carrolee Barlow +9 more
TL;DR: Divergent levels of sex chromosome aneuploidy are observed in the adult cerebral cortex of three genetic mutants, lending increasing support to the hypothesis that hereditary mutations such as ATM-deficiency can lead to late-manifesting human neurological disorders.