Robert Hauffe
University of Potsdam
12 Papers
9 Citations
Robert Hauffe is an academic researcher from University of Potsdam. The author has contributed to research in topics: Insulin resistance & Internal medicine. The author has an hindex of 2, co-authored 3 publications.
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Papers
Insulin action in the brain regulates mitochondrial stress responses and reduces diet-induced weight gain.
Kristina Wardelmann,Sabine Blümel,Michaela Rath,Eugenia Alfine,Chantal Chudoba,Mareike Schell,Weikang Cai,Robert Hauffe,Kathrin Warnke,Tanina Flore,Katrin Ritter,Jürgen Weiß,C. Ronald Kahn,André Kleinridders +13 more
TL;DR: Insulin via ERK activation increases the expression of MSR genes in vitro as well as in the hypothalamus of streptozotocin-treated mice, and regulation propagates mitochondrial function by controlling mitochondrial proteostasis and preventing excessive autophagy under serum deprivation.
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GPx3 dysregulation impacts adipose tissue insulin receptor expression and sensitivity.
Robert Hauffe,Vanessa Stein,Chantal Chudoba,Tanina Flore,Michaela Rath,Katrin Ritter,Mareike Schell,Kristina Wardelmann,Stefanie Deubel,Johannes F. Kopp,Maria Luiza Schwarz,Kai Kappert,Matthias Blüher,Tanja Schwerdtle,Anna P. Kipp,André Kleinridders +15 more
TL;DR: GPx3 is identified as a novel regulator of IR expression and insulin sensitivity in adipose tissue and feeding mice a selenium-enriched high-fat diet alleviates diet-induced insulin resistance with increased insulin sensitivity, decreased tissue inflammation and elevated IR expression in WAT.
HSP60 reduction protects against diet-induced obesity by modulating energy metabolism in adipose tissue.
Robert Hauffe,Michaela Rath,Mareike Schell,Katrin Ritter,Kai Kappert,Stefanie Deubel,Christiane Ott,Markus Jähnert,Wenke Jonas,Annette Schürmann,André Kleinridders +10 more
TL;DR: In this paper, the effect of a reduced HSP60 expression on the development of obesity and insulin resistance was investigated in heterozygous whole-body HSP 60 knockout mice.
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Obesity Hinders the Protective Effect of Selenite Supplementation on Insulin Signaling
Robert Hauffe,Michaela Rath,Wilson Agyapong,Wenke Jonas,Heike Vogel,Tim J. Schulz,Maria Schwarz,Anna P. Kipp,Matthias Blüher,André Kleinridders +9 more
TL;DR: Overall, while selenite protects against palmitate-induced insulin resistance in vitro, obesity impedes the effect of selenites on insulin action and adipose tissue metabolism in vivo.
Lactobacillus rhamnosus attenuates sex-specifically depressive-like behavior and mitigates metabolic consequences in obesity
Mareike Schell,Kristina Wardelmann,Robert Hauffe,Michaela Rath,Simran Chopra,André Kleinridders +5 more
TL;DR: It is shown that LR attenuates depressive-like behavior after established obesity, with changes in the dopaminergic system in male mice, and mitigates hyperinsulinemia in obese female mice.
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