Robert Grealy
Trinity College, Dublin
11 Papers
8 Citations
Robert Grealy is an academic researcher from Trinity College, Dublin. The author has contributed to research in topics: Sepsis & Immune system. The author has an hindex of 6, co-authored 10 publications.
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Papers
The Myeloid Transcription Factor KLF2 Regulates the Host Response to Polymicrobial Infection and Endotoxic Shock
Ganapati H. Mahabeleshwar,Daiji Kawanami,Nikunj Sharma,Yoichi Takami,Guangjin Zhou,Hong Shi,Lalitha Nayak,Darwin Jeyaraj,Robert Grealy,Mary C. White,Ross McManus,Thomas J. Ryan,Patrick Leahy,Zhiyong Lin,Saptarsi M. Haldar,G. Brandon Atkins,Hector R. Wong,Jerry B. Lingrel,Mukesh K. Jain +18 more
TL;DR: In this paper, the authors identify the Kruppel-like transcription factor 2 (KLF2) as a potent regulator of myeloid cell activation in vivo, and demonstrate that exposure to either hypoxia and/or bacterial products reduced KLF2 expression while inducing hypoxyia inducible factor 1α (HIF-1α), findings that were recapitulated in human septic patients.
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Circulating CD56dim natural killer cells and CD56+ T cells that produce interferon‐γ or interleukin‐10 are expanded in asymptomatic, E antigen‐negative patients with persistent hepatitis B virus infection
M. J. Conroy,M. J. Conroy,R. Mac Nicholas,Robert Grealy,M. Taylor,J. A. Otegbayo,S. O'Dea,Fiona Mulcahy,Thomas J. Ryan,Suzanne Norris,Derek G. Doherty,Derek G. Doherty +11 more
TL;DR: The frequencies, phenotypes, cytolytic activities and cytokine profiles of circulating natural killer cells, CD1d‐restricted invariant natural killer T (iNKT) cells and CD56+ T cells in 102 asymptomatic HBV‐infected patients and compared them with those in 66 uninfected control subjects were examined.
23
Interleukin-15 is associated with disease severity in viral bronchiolitis.
T. Ronan Leahy,Ross McManus,Derek G. Doherty,Robert Grealy,Tanya I. Coulter,Paul Smyth,Gordon Blackshields,Orla Sheils,Michael J. Carr,Nikhil Purandare,Michael Geary,Hennie M. Hodemaekers,Riny Janssen,Louis Bont,Dubhfeasa Slattery,Thomas J. Ryan +15 more
TL;DR: Investigating the innate cytokine interleukin-15 (IL-15) as a marker of disease severity in children hospitalised with viral bronchiolitis found IL-15 levels correlated with disease severity, and targets of de-regulated miRNA were differentially expressed in broncholitis.
21
Transforming growth factor beta-1 and interleukin-17 gene transcription in peripheral blood mononuclear cells and the human response to infection.
Mary C. White,Matthew W. Lawless,Michael J. O’Dwyer,Robert Grealy,Brian O. Connell,Patrick Stordeur,Dermot Kelleher,Ross McManus,Thomas J. Ryan +8 more
TL;DR: Down regulation of TGFbeta-1 gene transcription was related to the occurrence of infection but not the onset of sepsis, and interleukin-17 production in PBMC may not be significant in the human host response to infection.
20
Viral Bronchiolitis is Associated With Altered Cytokine Gene Expression and Lymphocyte Activation Status.
T. Leahy,Ross McManus,Derek G. Doherty,Robert Grealy,Michael J. Carr,Dubhfeasa Slattery,Thomas J. Ryan +6 more
TL;DR: Viral bronchiolitis is characterized by a distinct pattern of cytokine expression and lymphocyte activation that suggest an inadequate innate response in severe disease, and may offer potential as markers of disease severity.
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