Robert G. Johnson
United States Military Academy
16 Papers
340 Citations
Robert G. Johnson is an academic researcher from United States Military Academy. The author has contributed to research in topics: Phospholamban & Restenosis. The author has an hindex of 10, co-authored 16 publications.
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Papers
Solution structure of the cytoplasmic domain of phopholamban: phosphorylation leads to a local perturbation in secondary structure.
R.J. Mortishire-Smith,Steven M. Pitzenberger,C J Burke,C R Middaugh,Victor M. Garsky,Robert G. Johnson +5 more
TL;DR: 3JHN alpha coupling constants measured for I12, R13, A15, and S16 suggest that residues 12-16 undergo a local unwinding of the helix upon phosphorylation, suggesting a model forosphorylation-induced dissociation of the PLB/Ca(2+)-ATPase complex.
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Interaction of Cardiotonic Thiadiazinone Derivatives with Cardiac Troponin C
Bo-Sheng Pan,Robert G. Johnson +1 more
TL;DR: This study tested whether EMD 57033 interacts directly with recombinant human cardiac TnC (hcTnC), and found that a E MD 57033-binding site is induced by Ca2+ binding, but not Mg2- binding, to the Ca2-/Mg2+ sites of hcTNC.
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Dissociation of Phospholamban Regulation of Cardiac Sarcoplasmic Reticulum Ca2+ATPase by Quercetin
Edward McKenna,Jeffrey S. Smith,Kathleen E. Coll,Elaine K. Mazack,Ernest J. Mayer,Joanne Antanavage,Richard T. Wiedmann,Robert G. Johnson +7 more
TL;DR: Quercetin, even under stimulatory conditions, was a competitive inhibitor of ATP, but appears to relieve the Ca2+ATPase from phospholamban inhibition, thereby, producing an activation.
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Cloning and chromosomal localization of the human A2b adenosine receptor gene (ADORA2B) and its pseudogene.
TL;DR: Partial sequence analysis of the A2b gene (AD-ORA2B) revealed an intron that interrupted the coding region corresponding to the second intracellular loop similar to that reported for A1 and A2a adenosine receptor genes.
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Discovery of L-162,313: a nonpeptide that mimics the biological actions of angiotensin II
Salah D. Kivlighn,William R. Huckle,Gloria J. Zingaro,R. A. Rivero,Victor J. Lotti,R. S. L. Chang,Terry W. Schorn,N. Kevin,Robert G. Johnson,William J. Greenlee +9 more
TL;DR: In vitro, L-162,313-activated phosphoinositide turnover in rat aortic smooth muscle cell cultures was also blocked by L-158,809 and losartan (DuP-753), and the first reported nonpeptide ANG II receptor agonist is reported.
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