Robert E.W. Fyffe
Wright State University
59 Papers
672 Citations
Robert E.W. Fyffe is an academic researcher from Wright State University. The author has contributed to research in topics: Renshaw cell & Postsynaptic potential. The author has an hindex of 31, co-authored 57 publications.
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Papers
A functional role for the two-pore domain potassium channel TASK-1 in cerebellar granule neurons.
Julie A. Millar,Lynne Barratt,Andrew P. Southan,Karen M. Page,Robert E.W. Fyffe,Brian D. Robertson,Alistair Mathie +6 more
TL;DR: This description of a functional two-pore domain potassium channel in the mammalian central nervous system indicates its physiological importance in controlling cell excitability and how agents that modify its activity, such as agonists at G protein-coupled receptors and hydrogen ions, can profoundly alter both the neuron's resting potential and its excitability.
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Is ATP a central synaptic mediator for certain primary afferent fibers from mammalian skin
Robert E.W. Fyffe,Edward R. Perl +1 more
TL;DR: The results suggest the presence of a purinergic exciteatory receptor on central neurons receiving excitatory projection from tactile mechanoreceptors with fine-diameter afferent fibers and are consistent with the possibility that an ATP-like agent may mediate central synaptic excitation for this set of sense organs.
170
The continuing case for the Renshaw cell.
TL;DR: It is illustrated how mature Renshaw cell properties and connectivity arise through a combination of activity‐dependent and genetically specified mechanisms.
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Distribution of 5-hydroxytryptamine-immunoreactive boutons on alpha-motoneurons in the lumbar spinal cord of adult cats.
Francisco J. Alvarez,John C. Pearson,Deborah Harrington,Dianne E. Dewey,L. Torbeck,Robert E.W. Fyffe +5 more
TL;DR: This work examined identified motoneurons in vivo with a combination of immunohistochemical localization of 5‐HT‐immunoreactive boutons and intracellular staining with horseradish peroxidase to determine the spatial distribution of direct inputs from the serotonin system on the proximal and distal dendrites of individual mot oneurons.
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Cell-type specific organization of glycine receptor clusters in the mammalian spinal cord
TL;DR: The results indicate that mechanisms regulating receptor clustering do so primarily in the context of the postsynaptic neuron identity and localization in the dendritic arbor.
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