Robert E. Holmes
Medical University of South Carolina
10 Papers
118 Citations
Robert E. Holmes is an academic researcher from Medical University of South Carolina. The author has contributed to research in topics: Heterotopic ossification & Medicine. The author has an hindex of 5, co-authored 10 publications.
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Papers
Chondrosarcoma of bone.
Lee R. Leddy,Robert E. Holmes +1 more
TL;DR: Chondrosarcoma is a cartilage forming neoplasm, which is the second most common primary malignancy of bone, and is resistant to both chemotherapy and radiation, making wide local excision the only treatment.
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Heterotopic Ossification in Trauma.
TL;DR: Better understanding of the biology of heterotopic ossification (HO) formation will lead to treatment and prevention modalities that can be directed specifically at the cellular level, and surgeons will be able to individualize preemptive treatment to suppress inflammation and formation of HO.
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Pulsatile Lavage of Musculoskeletal Wounds Causes Muscle Necrosis and Dystrophic Calcification in a Rat Model.
Alexander M Chiaramonti,Astor Robertson,Thao Nguyen,David E. Jaffe,E. Lex Hanna,Robert E. Holmes,William R. Barfield,William L. Fourney,Joseph P. Stains,Vincent D. Pellegrini +9 more
TL;DR: Pulsatile lavage of musculoskeletal wounds can cause irreversible insult to tissue, resulting in myonecrosis and dystrophic calcification, and the benefits and offsetting harm of pulsatilelavage (20 psi) should be considered before its routine use in the management of muscles.
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Failure of Indomethacin and Radiation to Prevent Blast-induced Heterotopic Ossification in a Sprague-Dawley Rat Model.
Astor Robertson,Alexander M Chiaramonti,Thao Nguyen,David M. Jaffe,Robert E. Holmes,E L Hanna,Juong Rhee,William R. Barfield,William L. Fourney,Joseph P. Stains,Vincent D. Pellegrini +10 more
TL;DR: It is unexpectedly demonstrated that, compared with controls, indomethacin and irradiation provide no effective prophylaxis against HO in the residual limb after high-energy blast amputation in a rat model.
13
External Beam Irradiation Preferentially Inhibits the Endochondral Pathway of Fracture Healing: A Rat Model.
Yongren Wu,E. Lex Hanna,Robert E. Holmes,Zilan Lin,Alexander M Chiaramonti,Russell A. Reeves,Daniel G. McDonald,Kenneth N. Vanek,William R. Barfield,Hai Yao,Vincent D. Pellegrini +10 more
TL;DR: In this model, external beam irradiation was found to preferentially inhibit endochondral over intramembranous ossification with the greatest impairment in healing of radiated fractures repaired with intramedullary nails compared with those fixed with plates.
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