Before enzymes and templates: theory of surface metabolism.

Groundworks for an evolutionary biochemistry: The iron-sulphur world

The properties of streptavidin, a biotin-binding protein produced by streptomycetes.

A metabolic system composed of nucleic acid enzymes is proposed to have existed prior to the evolution of ribosomal protein synthesis. Vestiges of these nucleic acid enzymes persist in contemporary coenzymes. This proposal rationalizes the fact that many coenzymes are nucleotides or heterocyclic bases which could be derived from nucleotides.

Coenzymes as fossils of an earlier metabolic state

Lu Shin Wong graduated with a Bachelor of Pharmacy from the University of Nottingham in 1997. He then practiced as a hospital pharmacist for four years while completing his postgraduate diploma in clinical pharmacy from the University of Bradford. Subsequently, he undertook his Ph.D. studies at the University of Southampton with Prof. Mark Bradley on solid-phase organic chemistry, microspectrometry, and solid-supported sensors. Upon completing this in 2005, he joined the Manchester Interdisciplinary Biocentre as a postdoctoral research associate with Prof. Jason Micklefield on the application of chemical biology to surface chemistry and biomolecular-array technologies. Lu Shin is currently an EPSRC Life Science Interface research fellow, and his interests include the combination of chemical biology, surface chemistry, and nanofabrication towards life science applications.
Biography
Farid Khan obtained his Ph.D. from the University of Cambridge (2004), where he studied the folding of GFP using fluorescence and NMR. Previously, he has worked for a number of years at GlaxoSmithKline in fluorescence assay development for drug discovery. He spent two years as a postdoctoral researcher at the Babraham Institute in Cambridge, where he codeveloped novel protein arrays from DNA arrays using cell free synthesis and characterized robust protein immobilization methods. He is currently employed at the University of Manchester as a Systems Biologist at the Manchester Centre of Integrative Systems Biology. His primary role is on the characterizing of enzymes in metabolic pathways, and he is a M.Sc. lecturer in Biotechnology and Enterprise. He is a founder of Lumophore Ltd., a consulting company specializing in applications of protein array technology.
Biography
Jason Micklefield graduated from the University of Cambridge in 1993 with a Ph.D. in Organic Chemistry, working with Prof. Sir Alan R. Battersby to complete the first total synthesis of Haem d1. He then moved to the University of Washington, U.S.A., as a NATO postdoctoral fellow with Prof. Heinz G. Floss, investigating various biosynthetic pathways and enzyme mechanisms. In 1995 he began his independent research career as a Lecturer in Chemistry at Birkbeck College, University of London, before moving to Manchester in 1998, where he is now Chair of Chemical Biology. Prof. Micklefield?s research interests are at the chemistry?biology interface and include the redesign of nucleic acids, small-molecule control of gene expression, biosynthesis and biosynthetic engineering, nonribosomal peptides, biocatalysis, and enzyme mechanism.

Selective covalent protein immobilization: strategies and applications.

A Quantitative Test for Biotin and Observations Regarding its Occurrence and Properties

The concentration and assay of avidin, the injury-producing protein in raw egg white

5(4)-amino-4(5)-imidazolecarboxamide, a precursor of purines

Erythein and apoerythein and their relation to the antipernicious anemia principle.

https://science.sciencemag.org/content/sci/93/2420/477.full.pdf

Egg-white injury as the result of nonabsorption or inactivation of biotin.

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