Robert E. Beardmore
University of Exeter
54 Papers
229 Citations
Robert E. Beardmore is an academic researcher from University of Exeter. The author has contributed to research in topics: Biology & Population. The author has an hindex of 20, co-authored 51 publications. Previous affiliations of Robert E. Beardmore include Imperial College London & Brunel University London.
Chat about Author
Papers
Alternative Evolutionary Paths to Bacterial Antibiotic Resistance Cause Distinct Collateral Effects.
Camilo Barbosa,Vincent Trebosc,Christian Kemmer,Philip Rosenstiel,Robert E. Beardmore,Hinrich Schulenburg,Gunther Jansen +6 more
TL;DR: Collateral sensitivity can result from resistance mutations in regulatory genes such as nalC or mexZ, which mediate aminoglycoside sensitivity in β-lactam-adapted populations, or the two-component regulatory system gene pmrB, which enhances penicillin sensitivity in gentamicin-resistant populations, which in turn determine their potential in antibiotic therapy.
Antibiotic combination efficacy (ACE) networks for a Pseudomonas aeruginosa model.
TL;DR: The systematic experimental analysis allowed us to pinpoint 2 complementary determinants of combination efficacy and to identify specific drug pairs with high ACE scores, which can guide attempts to further improve the sustainability of antibiotic therapy by simultaneously reducing pathogen load and resistance evolution.
Constraints on microbial metabolism drive evolutionary diversification in homogeneous environments
TL;DR: This paper investigates the role of two established biochemical trade‐offs in microbial diversification using a model that connects ecological and evolutionary processes with fundamental aspects of biochemistry, and shows that these biochemical trade-offs can drive evolutionary diversification under the simplest possible ecological conditions.
72
The Singularity-Induced Bifurcation and its Kronecker Normal Form
TL;DR: It is shown that the singularity-induced bifurcation theorem can be expressed as the perturbation of an infinite eigenvalue of a particular class of parameterized index-1 matrix pencil, denoted $(M,L(\lambda)%), which has two purely imaginary eigenvalues near infinity.
71
Biophysical mechanisms that maintain biodiversity through trade-offs
TL;DR: In this article, the geometry of two trade-offs is derived from fundamental principles of living cells and used to predict stable genetic polymorphisms in Escherichia coli mutants that vary in a nutrient transporter, LamB.