Robert DeLotto
University of Copenhagen
14 Papers
319 Citations
Robert DeLotto is an academic researcher from University of Copenhagen. The author has contributed to research in topics: Protease & Biology. The author has an hindex of 12, co-authored 14 publications.
Chat about Author
Papers
Dynamics of the Dorsal morphogen gradient.
Jitendra Kanodia,Richa Rikhy,Yoosik Kim,Viktor K. Lund,Robert DeLotto,Jennifer Lippincott-Schwartz,Stanislav Y. Shvartsman +6 more
TL;DR: A mathematical model of the Dl gradient is developed and predicted that it is dynamic and can be described as a concentration profile with increasing amplitude and constant shape, different from those of the Bicoid and MAPK phosphorylation gradients, which pattern the anterior and terminal regions of the embryo.
128
Nucleocytoplasmic shuttling mediates the dynamic maintenance of nuclear Dorsal levels during Drosophila embryogenesis.
TL;DR: A model is proposed in which the generation and maintenance of the Dorsal gradient is a consequence of an active process involving both restricted long-range diffusion and the balancing of nuclear import with nuclear export.
Autoproteolysis and feedback in a protease cascade directing Drosophila dorsal–ventral cell fate
TL;DR: The results indicate that the three proteases do function in a sequential activation cascade, that GD becomes active and initiates the cascade and that interaction between GD and Snk is sufficient for GD to cleave itself autoproteolytically.
Molecular cloning, functional expression, and gene silencing of two Drosophila receptors for the Drosophila neuropeptide pyrokinin-2.
Carina Rosenkilde,Giuseppe Cazzamali,Michael Williamson,Frank Hauser,Leif Søndergaard,Robert DeLotto,Cornelis J. P. Grimmelikhuijzen +6 more
TL;DR: Gene silencing, using the RNA-mediated interference technique, showed that CG8784 gene silencing caused lethality in embryos, whereas CG8795 genesilencing resulted in strongly reduced viability for both embryos and first instar larvae.
86
Horseshoe crab coagulogen is an invertebrate protein with a nerve growth factor-like domain
TL;DR: The putative structural similarity of coagulogen and the Drosophila morphogen Spaetzle as well as the homology of its processing proteinases suggests a common origin of the two functionally different cascades.
45