Robert De Rose
University of Melbourne
76 Papers
1K Citations
Robert De Rose is an academic researcher from University of Melbourne. The author has contributed to research in topics: Pigtail macaque & Simian immunodeficiency virus. The author has an hindex of 29, co-authored 68 publications. Previous affiliations of Robert De Rose include Australian Research Council & Monash University.
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Papers
A Protective Vaccine Delivery System for In Vivo T Cell Stimulation Using Nanoengineered Polymer Hydrogel Capsules
Amy Sexton,Paul G. Whitney,Siow-Feng Chong,Alexander N. Zelikin,Angus P. R. Johnston,Robert De Rose,Andrew G. Brooks,Frank Caruso,Stephen J. Kent +8 more
TL;DR: In vitro and in vivo immunostimulatory capabilities of LbL-assembled disulfide cross-linked poly(methacrylic acid) (PMA(SH)) hydrogel capsules as a delivery strategy for protein and peptide vaccines are reported on and it is demonstrated that OVA protein as well as multiple OVA peptides can be successfully encapsulated within nanoengineered PMA(SH) hydrogels.
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Engineering poly(ethylene glycol) particles for improved biodistribution
Jiwei Cui,Robert De Rose,Karen Alt,Sheilajen Alcantara,Brett M. Paterson,Kang Liang,Ming Hu,Joseph J. Richardson,Yan Yan,Charmaine M. Jeffery,Charmaine M. Jeffery,Roger I. Price,Roger I. Price,Karlheinz Peter,Christoph E. Hagemeyer,Paul S. Donnelly,Stephen J. Kent,Frank Caruso +17 more
TL;DR: The engineering of poly(ethylene glycol) (PEG) hydrogel particles using a mesoporous silica (MS) templating method via tuning the PEG molecular weight, particle size, and the presence or absence of the template indicates a new class of polymer carriers with potential biomedical applications.
Binding, Internalization, and Antigen Presentation of Vaccine‐Loaded Nanoengineered Capsules in Blood
Robert De Rose,Alexander N. Zelikin,Angus P. R. Johnston,Amy Sexton,Siow-Feng Chong,Christina Cortez,William Mulholland,Frank Caruso,Stephen J. Kent +8 more
TL;DR: It is shown thatmixing free peptides with macaque monkey bloodcells effectively stimulates T cell immunity and prevents AIDS in SIV-infected monkeys.
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Simian Immunodeficiency Virus Infects Follicular Helper CD4 T Cells in Lymphoid Tissues during Pathogenic Infection of Pigtail Macaques
Yin Xu,Chris Weatherall,Michelle Bailey,Sheilajen Alcantara,Robert De Rose,Jérôme Estaquier,Jérôme Estaquier,Kim Wilson,Kazuo Suzuki,Jacques Corbeil,David A. Cooper,David A. Cooper,Stephen J. Kent,Anthony D. Kelleher,Anthony D. Kelleher,John Zaunders,John Zaunders +16 more
TL;DR: Early infection of Tfh cells represents an unexpected focus of viral infection and may be a factor that limits the quality of antibody responses and has implications for assessing the size of the viral reservoir.
102
Control of Viremia and Prevention of AIDS following Immunotherapy of SIV-Infected Macaques with Peptide-Pulsed Blood
Robert De Rose,Caroline S. Fernandez,Miranda Zoe Denham Smith,C. Jane Batten,Sheilajen Alcântara,Vivienne Peut,Erik Rollman,Liyen Loh,Rosemarie D. Mason,Kim Wilson,Matthew Law,Amanda J. Handley,Stephen J. Kent +12 more
TL;DR: High-level, SIV-specific CD4 and CD8 T-cell immunity was induced following immunization, both during antiretroviral cover and without, and a significant delay in AIDS-related mortality resulted.
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