Robert D. Nielsen
University of Washington
24 Papers
621 Citations
Robert D. Nielsen is an academic researcher from University of Washington. The author has contributed to research in topics: Chemistry & Biological membrane. The author has an hindex of 12, co-authored 24 publications. Previous affiliations of Robert D. Nielsen include ExxonMobil & University of Maryland, Baltimore.
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Papers
Docking Phospholipase A2 on Membranes Using Electrostatic Potential-Modulated Spin Relaxation Magnetic Resonance
Ying Lin,Robert D. Nielsen,Diana Murray,Wayne L. Hubbell,Colin Mailer,Bruce H. Robinson,Michael H. Gelb +6 more
TL;DR: A method involving electron paramagnetic resonance spectroscopy of a site-selectively spin-labeled peripheral membrane protein in the presence and absence of membranes and of a water-soluble spin relaxant has been developed to determine how bee venom phospholipase A2 sits on the membrane.
Interfacial membrane docking of cytosolic phospholipase A2 C2 domain using electrostatic potential-modulated spin relaxation magnetic resonance
TL;DR: The structure reveals that the two calcium-binding regions on C2cPLA2 that display hydrophobic residues are partially inserted into the core of the membrane, providing structural support for previous proposals that binding of C2 cPLA2 to the membrane interface is driven in part by insertion of hydrophilic surface loops into the membrane core.
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Esters of 5-carboxyl-5-methyl-1-pyrroline N-oxide: a family of spin traps for superoxide.
Pei Tsai,Kazuhiro Ichikawa,Colin Mailer,Sovitj Pou,Howard J. Halpern,Bruce H. Robinson,Robert D. Nielsen,Gerald M. Rosen +7 more
TL;DR: The results clearly demonstrated that EPR spectra of all the aminoxyls were inconsistent with a model that included a single gamma-hydrogen splitting, and a better interpretation modeled them as two diastereomers with identical nitrogen splittings and slightly different beta-Hydrogensplittings.
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Systematic development of high bandwidth, low drive voltage organic electro-optic devices and their applications
TL;DR: In this article, organic electro-optic (EO) materials have been presented that exhibit EO coefficients in the range of 60-100 pm/V at the telecommunications wavelengths of 1.3 and 1.55 μm.
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A ruler for determining the position of proteins in membranes.
TL;DR: The peptide ruler was used to determine the depth of penetration of the calcium-binding loops of the C2 domain of cytosolic phospholipase A(2), which compared favorably with previous determinations using more complex methods.
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