Robert D. Cole
University of Kentucky
4 Papers
Robert D. Cole is an academic researcher from University of Kentucky. The author has contributed to research in topics: Nicotine & Offspring. The author has an hindex of 3, co-authored 4 publications. Previous affiliations of Robert D. Cole include University of South Carolina.
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Papers
Microglia morphology and proinflammatory signaling in the nucleus accumbens during nicotine withdrawal
Adewale Adeluyi,Lindsey Guerin,Miranda L. Fisher,Miranda L. Fisher,Ashley Galloway,Robert D. Cole,Robert D. Cole,Sherine S.L. Chan,Michael D. Wyatt,Shannon W. Davis,Linnea R. Freeman,Pavel I. Ortinski,Pavel I. Ortinski,Jill R. Turner,Jill R. Turner +14 more
TL;DR: It is shown that both nicotine and withdrawal induce microglial morphological changes; however, proinflammatory effects and anxiogenic behaviors were observed only during nicotine withdrawal, and pharmacological microglia depletion during withdrawal prevented these effects.
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Paternal nicotine enhances fear memory, reduces nicotine administration, and alters hippocampal genetic and neural function in offspring.
Lisa R. Goldberg,Dana Zeid,Munir Gunes Kutlu,Robert D. Cole,Valeria Lallai,Aswathy Sebastian,Istvan Albert,Christie D. Fowler,Vinay Parikh,Thomas J. Gould +9 more
TL;DR: Paternal nicotine exposure was associated with enhanced contextual and cued fear conditioning and spontaneous recovery of extinguished fear memories, and nicotine reinforcement was reduced in nicotine‐sired mice, as assessed in a self‐administration paradigm.
Altered gating of Kv1.4 in the nucleus accumbens suppresses motivation for reward
Bernadette O'Donovan,Adewale Adeluyi,Erin L. Anderson,Robert D. Cole,Jill R. Turner,Pavel I. Ortinski +5 more
TL;DR: It is found that substantial variability in willingness to exert effort for reward was not associated with operant responding under low-effort conditions or stress levels, and neuronal and behavioral outputs associated with low motivation were linked to faster inactivation of a voltage-gated potassium channel, Kv1.4.
Loss of KHSRP Increases Neuronal Growth and Synaptic Transmission and Alters Memory Consolidation Through RNA Stabilization
Sarah L. Olguin,Priyanka Patel,Michela Dell'Orco,Amy S. Gardiner,Robert D. Cole,Courtney N Buchanan,Anitha Sundara,Joann Mudge,Andrea M. Allan,Pavel I. Ortinski,Jonathan L. Brigman,Jeffery L. Twiss,Nora I. Perrone-Bizzozero +12 more
TL;DR: The results indicate that prenatal deletion of KHSRP impairs neuronal development resulting in alterations in neuronal morphology and function by changing post-transcriptional control of neuronal gene expression.