Robert D. Betterton
University of Arizona
12 Papers
Robert D. Betterton is an academic researcher from University of Arizona. The author has contributed to research in topics: Medicine & Blood–brain barrier. The author has an hindex of 1, co-authored 2 publications.
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Papers
Blood–Brain Barrier Transporters: Opportunities for Therapeutic Development in Ischemic Stroke
TL;DR: Current knowledge on specific BBB uptake transporters that can be targeted for improved neuroprotective drug delivery are reviewed and state-of-the-art perspectives on how transporter pharmacology can be integrated into preclinical stroke research are provided.
Transporter-Mediated Delivery of Small Molecule Drugs to the Brain: A Critical Mechanism That Can Advance Therapeutic Development for Ischemic Stroke
TL;DR: Current knowledge on specific BBB transporters that can be targeted for improvement of ischemic stroke treatment are reviewed and state-of-the-art perspectives on the rationale for considering BBB transport properties during discovery/development of stroke therapeutics are provided.
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Organic Cation Transporter (OCT/OCTN) Expression at Brain Barrier Sites: Focus on CNS Drug Delivery.
TL;DR: In this article, the authors reviewed current knowledge on localization, function, and regulation of OCT and OCTN isoforms at the BBB and BCSFB with a particular emphasis on how these transporters can be utilized for CNS delivery of therapeutic agents.
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Regulation of Blood-Brain Barrier Transporters by Transforming Growth Factor-β/Activin Receptor-Like Kinase 1 Signaling: Relevance to the Brain Disposition of 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Inhibitors (i.e., Statins)
Robert D. Betterton,Wazir Abdullahi,Erica I. Williams,Jeffrey J. Lochhead,Hrvoje Brzica,Joshua A Stanton,Elizabeth S. Reddell,Chidinma E Ogbonnaya,Thomas P. Davis,Patrick T. Ronaldson +9 more
TL;DR: Evidence is provided for differential regulation of Oatp1a4 by TGF-β/ALK1 signaling across brain regions, knowledge that is critical for development of therapeutic strategies to target Oatps at the BBB for CNS drug delivery.
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Oatp (Organic Anion Transporting Polypeptide)-Mediated Transport: A Mechanism for Atorvastatin Neuroprotection in Stroke
Erica I. Williams,Robert D. Betterton,Joshua A Stanton,Valeria M Moreno-Rodriguez,Jeffrey J. Lochhead,Thomas P. Davis,Patrick T. Ronaldson +6 more
TL;DR: It is demonstrated that neuroprotective effects of atorvastatin may require central nervous system delivery by Oatp-mediated transport at the blood-brain barrier, a mechanism that persists despite increased cerebrovascular permeability in ischemic stroke.
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