Robert Cornelison
National Institutes of Health
21 Papers
61 Citations
Robert Cornelison is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Biology & Cancer research. The author has an hindex of 12, co-authored 16 publications.
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Papers
•Journal Article
Multiple genes at 17q23 undergo amplification and overexpression in breast cancer.
Maarit Bärlund,Outi Monni,Juha Kononen,Robert Cornelison,Joachim Torhorst,Guido Sauter,Olli-P. Kallioniemi,Anne Kallioniemi +7 more
TL;DR: The data suggest that 17q23 amplification results in simultaneous up-regulation of several genes, whose increased biological activity may jointly contribute to the more aggressive clinical course observed in patients with 17q22-q24-amplified tumors.
227
RNAi microarray analysis in cultured mammalian cells.
Spyro Mousses,Natasha J. Caplen,Robert Cornelison,Don Weaver,Mark Basik,Sampsa Hautaniemi,Sampsa Hautaniemi,Abdel G. Elkahloun,Roberto de Alencar Lotufo,Ashish Choudary,Edward R. Dougherty,Edward Suh,Olli Kallioniemi,Olli Kallioniemi +13 more
TL;DR: This RNAi microarray platform, together with ongoing efforts to develop large-scale human siRNA libraries, should facilitate genomic-scale cell-based analyses of gene function and integrate experimental details, image analysis, data display, and data archiving.
217
•Journal Article
Clinical validation of candidate genes associated with prostate cancer progression in the CWR22 model system using tissue microarrays.
Spyro Mousses,Lukas Bubendorf,Urs Wagner,Galen Hostetter,Juha Kononen,Robert Cornelison,Natalie Goldberger,Abdel G. Elkahloun,Niels Willi,Pasi A. Koivisto,William Ferhle,Mark Raffeld,Guito Sauter,Olli-P. Kallioniemi +13 more
TL;DR: Two genes that were down-regulated during tumor progression in the CWR22 model system were validated in vivo: crystallin mu (CRYM) and a LIM-domain protein LMO4 both showed significantly lower mRNA levels in hormone-refractory tumors as compared with primary tumors.
180
Protein expression of platelet-derived growth factor receptor correlates with malignant histology and PTEN with survival in childhood gliomas.
Halldora K. Thorarinsdottir,Mariarita Santi,Robert McCarter,Elisabeth J. Rushing,Robert Cornelison,Alessandra Jales,Tobey J. MacDonald +6 more
TL;DR: High PDGFR protein expression is significantly associated with malignant histology in pediatric gliomas, but it does not represent an independent prognostic factor.
81
Expression of TGF-β signaling factors in invasive breast cancers: relationships with age at diagnosis and tumor characteristics
Jonine D. Figueroa,Kathleen C. Flanders,Montserrat Garcia-Closas,William F. Anderson,Xiaohong R. Yang,Rayna K. Matsuno,Máire A. Duggan,Ruth M. Pfeiffer,Akira Ooshima,Robert Cornelison,Gretchen L. Gierach,Louise A. Brinton,Jolanta Lissowska,Beata Peplonska,Lalage M. Wakefield,Mark E. Sherman +15 more
TL;DR: Evidence is provided that TGF-β signaling patterns vary by age and pathologic features of prognostic significance including ER expression, which warrant analysis in studies of clinical outcomes accounting for age, ER status and treatment.