Robert C. Klipp
Portland State University
19 Papers
31 Citations
Robert C. Klipp is an academic researcher from Portland State University. The author has contributed to research in topics: Ryanodine receptor & Chemistry. The author has an hindex of 4, co-authored 8 publications. Previous affiliations of Robert C. Klipp include Anschutz Medical Campus.
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Papers
Ion Transport across Biological Membranes by Carborane-Capped Gold Nanoparticles
Marcin P. Grzelczak,Stephen P. Danks,Robert C. Klipp,Domagoj Belić,Adnana Zaulet,Casper Kunstmann-Olsen,Dan F. Bradley,Tatsuya Tsukuda,Clara Viñas,Francesc Teixidor,Jonathan J. Abramson,Mathias Brust +11 more
TL;DR: It is demonstrated by potential-dependent fluorescence spectroscopy that polarized phospholipid membranes of vesicles can be depolarized by ion transport mediated by the particles, and that the particles act as alkali-ion-specific transporters across free-standing membranes under potentiostatic control.
Insights into the molecular mechanisms underlying the inhibition of acid-sensing ion channel 3 gating by stomatin.
TL;DR: It is suggested that stomatin binds to the C-terminus of ASIC3 and stabilizes the desensitized state via an interaction with the channels’ first transmembrane domain.
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Treatment of catecholaminergic polymorphic ventricular tachycardia in mice using novel RyR2-modifying drugs
Na Li,Qiongling Wang,Martha Sibrian-Vazquez,Robert C. Klipp,Julia O. Reynolds,Tarah A. Word,Larry D. Scott,Guy Salama,Robert M. Strongin,Jonathan J. Abramson,Xander H.T. Wehrens +10 more
TL;DR: Tetracaine derivatives represent a novel class of RyR2 stabilizing drugs that could be used for the treatment of the potentially fatal disorder catecholaminergic polymorphic ventricular tachycardia.
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Structural determinants of acid-sensing ion channel potentiation by single chain lipids
Robert C. Klipp,John R. Bankston +1 more
TL;DR: It is shown that PUFAs cause multiple gating changes in ASIC3 including shifting the pH dependence of activation, slowing the rate of desensitization, and increasing the current even at a saturating pH.
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Dynamic landscape of the intracellular termini of acid-sensing ion channel 1a
TL;DR: Two transition metal ion FRET methods are used to investigate the conformational dynamics of the termini at neutral and acidic pH to suggest that a new hypothesis for RIPK1 binding during stroke is needed.
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