Robert Busch
Boehringer Ingelheim
8 Papers
47 Citations
Robert Busch is an academic researcher from Boehringer Ingelheim. The author has contributed to research in topics: Enantioselective synthesis & Cationic polymerization. The author has an hindex of 3, co-authored 5 publications.
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Papers
A short total synthesis of (+)-omaezakianol via an epoxide-initiated cationic cascade reaction.
TL;DR: (+)-Omaezakianol was synthesized in only three steps from racemic chlorohydrin 4 by Shi epoxidation followed by cascade cyclization and reduction.
38
Enantioselective synthesis of diverse sulfinamides and sulfinylferrocenes from phenylglycine-derived chiral sulfinyl transfer agent.
Zhengxu S. Han,Angelica Meyer,Yibo Xu,Yongda Zhang,Robert Busch,Sherry Shen,Nelu Grinberg,Bruce Z. Lu,Dhileep Krishnamurthy,Chris H. Senanayake +9 more
TL;DR: A new chiral sulfinyl transfer auxiliary derived from readily available phenylglycine was developed and utilized to synthesize a diverse array of alkyl- and arylsulfinamides and sulfinylferrocenes in high yields and excellent ee's.
29
A Short Total Synthesis of (+)-Omaezakianol via an Epoxide-Initiated Cationic Cascade Reaction.
TL;DR: The key step in the synthesis of the title compound (III) is the transformation of the pentaepoxide (I) into the furan derivative (II) as discussed by the authors.
19
Asymmetric synthesis of diverse α,α-diarylmethylamines via aryl Grignard additions to chiral N-2,4,6-triisopropylbenzenesulfinylimines
Zhengxu Han,Robert Busch,Keith R. Fandrick,Angelica Meyer,Yibo Xu,Dhileep Krishnamurthy,Chris H. Senanayake +6 more
TL;DR: In this paper, a mild method was developed for the asymmetric synthesis of chiral diarylmethylamines via the addition of aryl Grignard reagents to chiral N-2,4,6-triisopropylbenzenesulfinylimines in high yields and high diastereoselectivities.
15
Asymmetric Synthesis of Diverse α,α-Diarylmethylamines via Aryl Grignard Additions to Chiral N-2,4,6-Triisopropylbenzenesulfinylimines.
Zhengxu Han,Robert Busch,Keith R. Fandrick,Angelica Meyer,Yibo Xu,Dhileep Krishnamurthy,Chris H. Senanayake +6 more
TL;DR: With the use of the sterically hindered auxiliary, the reactions conducted at room temperature proceed with higher conversions, reaction rates, and stereoselectivities compared to those at -40 °C as discussed by the authors.