Robert Blassberg
Francis Crick Institute
16 Papers
54 Citations
Robert Blassberg is an academic researcher from Francis Crick Institute. The author has contributed to research in topics: Biology & Gene. The author has an hindex of 8, co-authored 12 publications. Previous affiliations of Robert Blassberg include University of Oxford & National Institute for Medical Research.
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Papers
Ptch1 and Gli regulate Shh signalling dynamics via multiple mechanisms
Michael H Cohen,Anna Kicheva,Ana Ribeiro,Robert Blassberg,Karen M. Page,Chris P. Barnes,James Briscoe +6 more
TL;DR: The Shh gradient in the developing mouse neural tube is quantified and it is shown that while the amplitude of the gradient increases over time, the activity of the pathway transcriptional effectors, Gli proteins, initially increases but later decreases.
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Statistically derived geometrical landscapes capture principles of decision-making dynamics during cell fate transitions.
Tobias Schüttler,Meritxell Sáez,Meritxell Sáez,Robert Blassberg,Elena Camacho-Aguilar,Elena Camacho-Aguilar,Eric D. Siggia,David A. Rand,James Briscoe +8 more
TL;DR: In this paper, the authors combined principled statistical methods with a framework based on catastrophe theory and approximate Bayesian computation to formulate a quantitative dynamical landscape that accurately predicts cell fate outcomes.
97
PBX/extradenticle is required to re-establish axial structures and polarity during planarian regeneration
TL;DR: The data suggest that Smed-pbx functions as a central integrator of positional information to drive patterning of regeneration along the body axis, with a primary role in patterning the anterior-posterior (AP) axis and AP polarity.
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Sox2 levels regulate the chromatin occupancy of WNT mediators in epiblast progenitors responsible for vertebrate body formation
Robert Blassberg,Harshil Patel,Thomas Watson,Mina Gouti,Vicki Metzis,M. Joaquina Delás,James Briscoe +6 more
TL;DR: In this paper , the authors define a role for SOX2 levels in dictating the chromatin occupancy of TCF/β-catenin and reveal how context-specific responses to a signal are configured by the level of a transcription factor.
TRF2-independent chromosome end protection during pluripotency
Phil Ruis,David Van Ly,David Van Ly,Valerie Borel,Georgia R. Kafer,Afshan McCarthy,Steven Howell,Robert Blassberg,Ambrosius P. Snijders,James Briscoe,Kathy K. Niakan,Paulina Marzec,Anthony J. Cesare,Simon J. Boulton +13 more
TL;DR: Experiments in mouse pluripotent embryonic and epiblast stem cells show that TRF2 is dispensable for telomere protection specifically in the pluripotency cells that form during early embryonic development, when cells form T-loops independently of this protein.
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