Robert Bedford

TL;DR: Physiological parameters that mediate response saturation of rod photoreceptors in mouse retina are described, and it is shown that rods can drive visual responses in photopic conditions.

TL;DR: Electrophysiological activity in the mouse dorsal lateral geniculate nucleus is recorded under exposure to a simulated dawn to show that, over higher irradiances, this increase in firing originates with inner-retinal melanopsin photoreception and results in an up to threefold increase in single-trial reliability of fast visual responses.

TL;DR: Ectopically expressed human rod opsin, driven by either a non-selective or ON-bipolar cell-specific promoter, functioned outside native photoreceptors and restored visual function in rd1 mice, suggesting that rod Opsin merits consideration as an optogenetic actuator for treating patients with advanced retinal degeneration.

TL;DR: Direct evidence that an aspect of visual discrimination innormally sighted subjects can be supported by inner retinalphotoreceptors is shown, and this prediction of the hypothesis that intrinsically photore-ceptive retinal ganglion cells (ipRGCs) contribute to assessing brightness is confirmed.